Mucosal vaccination induces protection against SARS-CoV-2 in the absence of detectable neutralizing antibodies

A candidate multigenic SARS-CoV-2 vaccine based on an MVA vector expressing both viral N and S proteins (MVA-S + N) was immunogenic, and induced T-cell responses and binding antibodies to both antigens but in the absence of detectable neutralizing antibodies. Intranasal immunization with the vaccine...

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Detalles Bibliográficos
Autores principales: Zhong, Chaojie, Xia, Hongjie, Adam, Awadalkareem, Wang, Binbin, Hajnik, Renee L., Liang, Yuejin, Rafael, Grace H., Zou, Jing, Wang, Xiaofang, Sun, Jiaren, Soong, Lynn, Barrett, Alan D. T., Weaver, Scott C., Shi, Pei-Yong, Wang, Tian, Hu, Haitao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8630013/
https://www.ncbi.nlm.nih.gov/pubmed/34845215
http://dx.doi.org/10.1038/s41541-021-00405-5

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