Subclone-specific microenvironmental impact and drug response in refractory multiple myeloma revealed by single‐cell transcriptomics

Virtually all patients with multiple myeloma become unresponsive to treatment over time. Relapsed/refractory multiple myeloma (RRMM) is accompanied by the clonal evolution of myeloma cells with heterogeneous genomic aberrations and profound changes of the bone marrow microenvironment (BME). However,...

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Detalles Bibliográficos
Autores principales: Tirier, Stephan M., Mallm, Jan-Philipp, Steiger, Simon, Poos, Alexandra M., Awwad, Mohamed H. S., Giesen, Nicola, Casiraghi, Nicola, Susak, Hana, Bauer, Katharina, Baumann, Anja, John, Lukas, Seckinger, Anja, Hose, Dirk, Müller-Tidow, Carsten, Goldschmidt, Hartmut, Stegle, Oliver, Hundemer, Michael, Weinhold, Niels, Raab, Marc S., Rippe, Karsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8630108/
https://www.ncbi.nlm.nih.gov/pubmed/34845188
http://dx.doi.org/10.1038/s41467-021-26951-z

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