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The implications of hyperoxia, type 1 diabetes and sex on cardiovascular physiology in mice

Oxygen supplementation, although a cornerstone of emergency and cardiovascular medicine, often results in hyperoxia, a condition characterized by excessive tissue oxygen which results in adverse cardiac remodeling and subsequent injurious effects to physiological function. Cardiac remodeling is furt...

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Autores principales: Bojkovic, Katarina, Rodgers, Jennifer Leigh, Vichare, Riddhi, Nandi, Asmita, Mansour, Hussein, Saleem, Faizan, Abidin, Zain Ul, Vanthenapalli, Sahit, Cheng, Feng, Panguluri, Siva Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8630164/
https://www.ncbi.nlm.nih.gov/pubmed/34845324
http://dx.doi.org/10.1038/s41598-021-02550-2
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author Bojkovic, Katarina
Rodgers, Jennifer Leigh
Vichare, Riddhi
Nandi, Asmita
Mansour, Hussein
Saleem, Faizan
Abidin, Zain Ul
Vanthenapalli, Sahit
Cheng, Feng
Panguluri, Siva Kumar
author_facet Bojkovic, Katarina
Rodgers, Jennifer Leigh
Vichare, Riddhi
Nandi, Asmita
Mansour, Hussein
Saleem, Faizan
Abidin, Zain Ul
Vanthenapalli, Sahit
Cheng, Feng
Panguluri, Siva Kumar
author_sort Bojkovic, Katarina
collection PubMed
description Oxygen supplementation, although a cornerstone of emergency and cardiovascular medicine, often results in hyperoxia, a condition characterized by excessive tissue oxygen which results in adverse cardiac remodeling and subsequent injurious effects to physiological function. Cardiac remodeling is further influenced by various risk factors, including pre-existing conditions and sex. Thus, the purpose of this experiment was to investigate cardiac remodeling in Type I Diabetic (Akita) mice subjected to hyperoxic treatment. Overall, we demonstrated that Akita mice experience distinct challenges from wild type (WT) mice. Specifically, Akita males at both normoxia and hyperoxia showed significant decreases in body and heart weights, prolonged PR, QRS, and QTc intervals, and reduced %EF and %FS at normoxia compared to WT controls. Moreover, Akita males largely resemble female mice (both WT and Akita) with regards to the parameters studied. Finally, statistical analysis revealed hyperoxia to have the greatest influence on cardiac pathophysiology, followed by sex, and finally genotype. Taken together, our data suggest that Type I diabetic patients may have distinct cardiac pathophysiology under hyperoxia compared to uncomplicated patients, with males being at high risk. These findings can be used to enhance provision of care in ICU patients with Type I diabetes as a comorbid condition.
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spelling pubmed-86301642021-12-01 The implications of hyperoxia, type 1 diabetes and sex on cardiovascular physiology in mice Bojkovic, Katarina Rodgers, Jennifer Leigh Vichare, Riddhi Nandi, Asmita Mansour, Hussein Saleem, Faizan Abidin, Zain Ul Vanthenapalli, Sahit Cheng, Feng Panguluri, Siva Kumar Sci Rep Article Oxygen supplementation, although a cornerstone of emergency and cardiovascular medicine, often results in hyperoxia, a condition characterized by excessive tissue oxygen which results in adverse cardiac remodeling and subsequent injurious effects to physiological function. Cardiac remodeling is further influenced by various risk factors, including pre-existing conditions and sex. Thus, the purpose of this experiment was to investigate cardiac remodeling in Type I Diabetic (Akita) mice subjected to hyperoxic treatment. Overall, we demonstrated that Akita mice experience distinct challenges from wild type (WT) mice. Specifically, Akita males at both normoxia and hyperoxia showed significant decreases in body and heart weights, prolonged PR, QRS, and QTc intervals, and reduced %EF and %FS at normoxia compared to WT controls. Moreover, Akita males largely resemble female mice (both WT and Akita) with regards to the parameters studied. Finally, statistical analysis revealed hyperoxia to have the greatest influence on cardiac pathophysiology, followed by sex, and finally genotype. Taken together, our data suggest that Type I diabetic patients may have distinct cardiac pathophysiology under hyperoxia compared to uncomplicated patients, with males being at high risk. These findings can be used to enhance provision of care in ICU patients with Type I diabetes as a comorbid condition. Nature Publishing Group UK 2021-11-29 /pmc/articles/PMC8630164/ /pubmed/34845324 http://dx.doi.org/10.1038/s41598-021-02550-2 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Bojkovic, Katarina
Rodgers, Jennifer Leigh
Vichare, Riddhi
Nandi, Asmita
Mansour, Hussein
Saleem, Faizan
Abidin, Zain Ul
Vanthenapalli, Sahit
Cheng, Feng
Panguluri, Siva Kumar
The implications of hyperoxia, type 1 diabetes and sex on cardiovascular physiology in mice
title The implications of hyperoxia, type 1 diabetes and sex on cardiovascular physiology in mice
title_full The implications of hyperoxia, type 1 diabetes and sex on cardiovascular physiology in mice
title_fullStr The implications of hyperoxia, type 1 diabetes and sex on cardiovascular physiology in mice
title_full_unstemmed The implications of hyperoxia, type 1 diabetes and sex on cardiovascular physiology in mice
title_short The implications of hyperoxia, type 1 diabetes and sex on cardiovascular physiology in mice
title_sort implications of hyperoxia, type 1 diabetes and sex on cardiovascular physiology in mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8630164/
https://www.ncbi.nlm.nih.gov/pubmed/34845324
http://dx.doi.org/10.1038/s41598-021-02550-2
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