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Role of the trace amine associated receptor 5 (TAAR5) in the sensorimotor functions

Classical monoamines are well-known modulators of sensorimotor neural networks. However, the role of trace amines and their receptors in sensorimotor function remains unexplored. Using trace amine-associated receptor 5 knockout (TAAR5-KO) mice, that express beta-galactosidase mapping its localizatio...

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Autores principales: Kalinina, D. S., Ptukha, M. A., Goriainova, A. V., Merkulyeva, N. S., Kozlova, A. A., Murtazina, R. Z., Shemiakova, T. S., Kuvarzin, S. R., Vaganova, A. N., Volnova, A. B., Gainetdinov, R. R., Musienko, P. E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8630200/
https://www.ncbi.nlm.nih.gov/pubmed/34845253
http://dx.doi.org/10.1038/s41598-021-02289-w
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author Kalinina, D. S.
Ptukha, M. A.
Goriainova, A. V.
Merkulyeva, N. S.
Kozlova, A. A.
Murtazina, R. Z.
Shemiakova, T. S.
Kuvarzin, S. R.
Vaganova, A. N.
Volnova, A. B.
Gainetdinov, R. R.
Musienko, P. E.
author_facet Kalinina, D. S.
Ptukha, M. A.
Goriainova, A. V.
Merkulyeva, N. S.
Kozlova, A. A.
Murtazina, R. Z.
Shemiakova, T. S.
Kuvarzin, S. R.
Vaganova, A. N.
Volnova, A. B.
Gainetdinov, R. R.
Musienko, P. E.
author_sort Kalinina, D. S.
collection PubMed
description Classical monoamines are well-known modulators of sensorimotor neural networks. However, the role of trace amines and their receptors in sensorimotor function remains unexplored. Using trace amine-associated receptor 5 knockout (TAAR5-KO) mice, that express beta-galactosidase mapping its localization, we observed TAAR5 expression in the Purkinje cells of the cerebellum and the medial vestibular nucleus, suggesting that TAAR5 might be involved in the vestibular and motor control. Accordingly, in various behavioral tests, TAAR5-KO mice demonstrated lower endurance, but better coordination and balance compared to wild-type controls. Furthermore, we found specific changes in striatal local field potentials and motor cortex electrocorticogram, such as a decrease in delta and an increase in theta oscillations of power spectra, respectively. The obtained data indicate that TAAR5 plays a considerable role in regulation postural stability, muscle force, balance, and motor coordination during active movements, likely via modulation of monoaminergic systems at different levels of sensorimotor control involving critical brain areas such as the brainstem, cerebellum, and forebrain.
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spelling pubmed-86302002021-12-01 Role of the trace amine associated receptor 5 (TAAR5) in the sensorimotor functions Kalinina, D. S. Ptukha, M. A. Goriainova, A. V. Merkulyeva, N. S. Kozlova, A. A. Murtazina, R. Z. Shemiakova, T. S. Kuvarzin, S. R. Vaganova, A. N. Volnova, A. B. Gainetdinov, R. R. Musienko, P. E. Sci Rep Article Classical monoamines are well-known modulators of sensorimotor neural networks. However, the role of trace amines and their receptors in sensorimotor function remains unexplored. Using trace amine-associated receptor 5 knockout (TAAR5-KO) mice, that express beta-galactosidase mapping its localization, we observed TAAR5 expression in the Purkinje cells of the cerebellum and the medial vestibular nucleus, suggesting that TAAR5 might be involved in the vestibular and motor control. Accordingly, in various behavioral tests, TAAR5-KO mice demonstrated lower endurance, but better coordination and balance compared to wild-type controls. Furthermore, we found specific changes in striatal local field potentials and motor cortex electrocorticogram, such as a decrease in delta and an increase in theta oscillations of power spectra, respectively. The obtained data indicate that TAAR5 plays a considerable role in regulation postural stability, muscle force, balance, and motor coordination during active movements, likely via modulation of monoaminergic systems at different levels of sensorimotor control involving critical brain areas such as the brainstem, cerebellum, and forebrain. Nature Publishing Group UK 2021-11-29 /pmc/articles/PMC8630200/ /pubmed/34845253 http://dx.doi.org/10.1038/s41598-021-02289-w Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Kalinina, D. S.
Ptukha, M. A.
Goriainova, A. V.
Merkulyeva, N. S.
Kozlova, A. A.
Murtazina, R. Z.
Shemiakova, T. S.
Kuvarzin, S. R.
Vaganova, A. N.
Volnova, A. B.
Gainetdinov, R. R.
Musienko, P. E.
Role of the trace amine associated receptor 5 (TAAR5) in the sensorimotor functions
title Role of the trace amine associated receptor 5 (TAAR5) in the sensorimotor functions
title_full Role of the trace amine associated receptor 5 (TAAR5) in the sensorimotor functions
title_fullStr Role of the trace amine associated receptor 5 (TAAR5) in the sensorimotor functions
title_full_unstemmed Role of the trace amine associated receptor 5 (TAAR5) in the sensorimotor functions
title_short Role of the trace amine associated receptor 5 (TAAR5) in the sensorimotor functions
title_sort role of the trace amine associated receptor 5 (taar5) in the sensorimotor functions
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8630200/
https://www.ncbi.nlm.nih.gov/pubmed/34845253
http://dx.doi.org/10.1038/s41598-021-02289-w
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