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Pathogenesis of IgA Vasculitis: An Up-To-Date Review
Immunoglobin A (IgA) vasculitis (IgAV), formerly called the Henoch-Schönlein purpura (HSP), is a small vessel vasculitis, characterized by IgA1-dominant immune deposition at diseased vessel walls. IgAV is the most common form of vasculitis in children; typical symptoms include palpable purpura, arth...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8630619/ https://www.ncbi.nlm.nih.gov/pubmed/34858429 http://dx.doi.org/10.3389/fimmu.2021.771619 |
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author | Song, Yan Huang, Xiaohan Yu, Guizhen Qiao, Jianjun Cheng, Jun Wu, Jianyong Chen, Jianghua |
author_facet | Song, Yan Huang, Xiaohan Yu, Guizhen Qiao, Jianjun Cheng, Jun Wu, Jianyong Chen, Jianghua |
author_sort | Song, Yan |
collection | PubMed |
description | Immunoglobin A (IgA) vasculitis (IgAV), formerly called the Henoch-Schönlein purpura (HSP), is a small vessel vasculitis, characterized by IgA1-dominant immune deposition at diseased vessel walls. IgAV is the most common form of vasculitis in children; typical symptoms include palpable purpura, arthritis or arthralgia, abdominal pain, and hematuria or proteinuria. Galactose-deficient IgA1 is detected in the tissues of the kidney and skin in patients with IgAV; it forms immune complexes leading to subsequent immune reactions and injuries. This report provides the recent advances in the understanding of environmental factors, genetics, abnormal innate and acquired immunity, and the role of galactose-deficient IgA1 immunocomplexes in the pathogenesis of IgAV. |
format | Online Article Text |
id | pubmed-8630619 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-86306192021-12-01 Pathogenesis of IgA Vasculitis: An Up-To-Date Review Song, Yan Huang, Xiaohan Yu, Guizhen Qiao, Jianjun Cheng, Jun Wu, Jianyong Chen, Jianghua Front Immunol Immunology Immunoglobin A (IgA) vasculitis (IgAV), formerly called the Henoch-Schönlein purpura (HSP), is a small vessel vasculitis, characterized by IgA1-dominant immune deposition at diseased vessel walls. IgAV is the most common form of vasculitis in children; typical symptoms include palpable purpura, arthritis or arthralgia, abdominal pain, and hematuria or proteinuria. Galactose-deficient IgA1 is detected in the tissues of the kidney and skin in patients with IgAV; it forms immune complexes leading to subsequent immune reactions and injuries. This report provides the recent advances in the understanding of environmental factors, genetics, abnormal innate and acquired immunity, and the role of galactose-deficient IgA1 immunocomplexes in the pathogenesis of IgAV. Frontiers Media S.A. 2021-11-09 /pmc/articles/PMC8630619/ /pubmed/34858429 http://dx.doi.org/10.3389/fimmu.2021.771619 Text en Copyright © 2021 Song, Huang, Yu, Qiao, Cheng, Wu and Chen https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Song, Yan Huang, Xiaohan Yu, Guizhen Qiao, Jianjun Cheng, Jun Wu, Jianyong Chen, Jianghua Pathogenesis of IgA Vasculitis: An Up-To-Date Review |
title | Pathogenesis of IgA Vasculitis: An Up-To-Date Review |
title_full | Pathogenesis of IgA Vasculitis: An Up-To-Date Review |
title_fullStr | Pathogenesis of IgA Vasculitis: An Up-To-Date Review |
title_full_unstemmed | Pathogenesis of IgA Vasculitis: An Up-To-Date Review |
title_short | Pathogenesis of IgA Vasculitis: An Up-To-Date Review |
title_sort | pathogenesis of iga vasculitis: an up-to-date review |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8630619/ https://www.ncbi.nlm.nih.gov/pubmed/34858429 http://dx.doi.org/10.3389/fimmu.2021.771619 |
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