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Pathogenesis of IgA Vasculitis: An Up-To-Date Review

Immunoglobin A (IgA) vasculitis (IgAV), formerly called the Henoch-Schönlein purpura (HSP), is a small vessel vasculitis, characterized by IgA1-dominant immune deposition at diseased vessel walls. IgAV is the most common form of vasculitis in children; typical symptoms include palpable purpura, arth...

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Autores principales: Song, Yan, Huang, Xiaohan, Yu, Guizhen, Qiao, Jianjun, Cheng, Jun, Wu, Jianyong, Chen, Jianghua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8630619/
https://www.ncbi.nlm.nih.gov/pubmed/34858429
http://dx.doi.org/10.3389/fimmu.2021.771619
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author Song, Yan
Huang, Xiaohan
Yu, Guizhen
Qiao, Jianjun
Cheng, Jun
Wu, Jianyong
Chen, Jianghua
author_facet Song, Yan
Huang, Xiaohan
Yu, Guizhen
Qiao, Jianjun
Cheng, Jun
Wu, Jianyong
Chen, Jianghua
author_sort Song, Yan
collection PubMed
description Immunoglobin A (IgA) vasculitis (IgAV), formerly called the Henoch-Schönlein purpura (HSP), is a small vessel vasculitis, characterized by IgA1-dominant immune deposition at diseased vessel walls. IgAV is the most common form of vasculitis in children; typical symptoms include palpable purpura, arthritis or arthralgia, abdominal pain, and hematuria or proteinuria. Galactose-deficient IgA1 is detected in the tissues of the kidney and skin in patients with IgAV; it forms immune complexes leading to subsequent immune reactions and injuries. This report provides the recent advances in the understanding of environmental factors, genetics, abnormal innate and acquired immunity, and the role of galactose-deficient IgA1 immunocomplexes in the pathogenesis of IgAV.
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spelling pubmed-86306192021-12-01 Pathogenesis of IgA Vasculitis: An Up-To-Date Review Song, Yan Huang, Xiaohan Yu, Guizhen Qiao, Jianjun Cheng, Jun Wu, Jianyong Chen, Jianghua Front Immunol Immunology Immunoglobin A (IgA) vasculitis (IgAV), formerly called the Henoch-Schönlein purpura (HSP), is a small vessel vasculitis, characterized by IgA1-dominant immune deposition at diseased vessel walls. IgAV is the most common form of vasculitis in children; typical symptoms include palpable purpura, arthritis or arthralgia, abdominal pain, and hematuria or proteinuria. Galactose-deficient IgA1 is detected in the tissues of the kidney and skin in patients with IgAV; it forms immune complexes leading to subsequent immune reactions and injuries. This report provides the recent advances in the understanding of environmental factors, genetics, abnormal innate and acquired immunity, and the role of galactose-deficient IgA1 immunocomplexes in the pathogenesis of IgAV. Frontiers Media S.A. 2021-11-09 /pmc/articles/PMC8630619/ /pubmed/34858429 http://dx.doi.org/10.3389/fimmu.2021.771619 Text en Copyright © 2021 Song, Huang, Yu, Qiao, Cheng, Wu and Chen https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Song, Yan
Huang, Xiaohan
Yu, Guizhen
Qiao, Jianjun
Cheng, Jun
Wu, Jianyong
Chen, Jianghua
Pathogenesis of IgA Vasculitis: An Up-To-Date Review
title Pathogenesis of IgA Vasculitis: An Up-To-Date Review
title_full Pathogenesis of IgA Vasculitis: An Up-To-Date Review
title_fullStr Pathogenesis of IgA Vasculitis: An Up-To-Date Review
title_full_unstemmed Pathogenesis of IgA Vasculitis: An Up-To-Date Review
title_short Pathogenesis of IgA Vasculitis: An Up-To-Date Review
title_sort pathogenesis of iga vasculitis: an up-to-date review
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8630619/
https://www.ncbi.nlm.nih.gov/pubmed/34858429
http://dx.doi.org/10.3389/fimmu.2021.771619
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