Development of Indole Alkaloid-Type Dual Immune Checkpoint Inhibitors Against CTLA-4 and PD-L1 Based on Diversity-Enhanced Extracts

Cancer immunotherapy involves the use of the immune system for cancer treatment. Recently, immune checkpoint-blocking antibodies have become integral for the treatment of some cancers. However, small molecules exhibit advantages over monoclonal antibody drugs, such as cell penetration, long half-lif...

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Detalles Bibliográficos
Autores principales: Suzuki, Yoshihide, Ichinohe, Keisuke, Sugawara, Akihiro, Kida, Shinya, Murase, Shinya, Zhang, Jing, Yamada, Osamu, Hattori, Toshio, Oshima, Yoshiteru, Kikuchi, Haruhisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8630621/
https://www.ncbi.nlm.nih.gov/pubmed/34858943
http://dx.doi.org/10.3389/fchem.2021.766107

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