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Berberine-Loaded Biomimetic Nanoparticles Attenuate Inflammation of Experimental Allergic Asthma via Enhancing IL-12 Expression

Asthma is one of the most common chronic pulmonary disorders, affecting more than 330 million people worldwide. Unfortunately, there are still no specific treatments for asthma so far. Therefore, it is very important to develop effective therapeutics and medicines to deal with this intractable disea...

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Autores principales: Jin, Hua, Li, Jiale, Zhang, Miaoyuan, Luo, Renxing, Lu, Peishan, Zhang, Wenting, Zhang, Junai, Pi, Jiang, Zheng, Weixin, Mai, Zesen, Ding, Xiaowen, Liu, Xinguang, Ouyang, Suidong, Huang, Gonghua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8630696/
https://www.ncbi.nlm.nih.gov/pubmed/34858170
http://dx.doi.org/10.3389/fphar.2021.724525
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author Jin, Hua
Li, Jiale
Zhang, Miaoyuan
Luo, Renxing
Lu, Peishan
Zhang, Wenting
Zhang, Junai
Pi, Jiang
Zheng, Weixin
Mai, Zesen
Ding, Xiaowen
Liu, Xinguang
Ouyang, Suidong
Huang, Gonghua
author_facet Jin, Hua
Li, Jiale
Zhang, Miaoyuan
Luo, Renxing
Lu, Peishan
Zhang, Wenting
Zhang, Junai
Pi, Jiang
Zheng, Weixin
Mai, Zesen
Ding, Xiaowen
Liu, Xinguang
Ouyang, Suidong
Huang, Gonghua
author_sort Jin, Hua
collection PubMed
description Asthma is one of the most common chronic pulmonary disorders, affecting more than 330 million people worldwide. Unfortunately, there are still no specific treatments for asthma so far. Therefore, it is very important to develop effective therapeutics and medicines to deal with this intractable disease. Berberine (Ber) has fabulous anti-inflammatory and antibacterial effects, while its low water solubility and bioavailability greatly limit its curative efficiency. To improve the nasal mucosa absorption of poorly water-soluble drugs, such as Ber, we developed a platelet membrane- (PM-) coated nanoparticle (NP) system (PM@Ber-NPs) for targeted delivery of berberine to the inflammatory lungs. In vivo, PM@Ber-NPs exhibited enhanced targeting retention in the inflammatory lungs compared with free Ber. In a mouse model of house dust mite- (HDM-) induced asthma, PM@Ber-NPs markedly inhibited lung inflammation, as evident by reduced inflammatory cells and inflammatory cytokines in the lung compared with free Ber. Collectively, our study demonstrated the inhibitory actions of nasally delivered nanomedicines on HDM-induced asthma, primarily through regulating Th1/Th2 balance by enhancing IL-12 expression which could potentially reduce lung inflammation and allergic asthma.
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spelling pubmed-86306962021-12-01 Berberine-Loaded Biomimetic Nanoparticles Attenuate Inflammation of Experimental Allergic Asthma via Enhancing IL-12 Expression Jin, Hua Li, Jiale Zhang, Miaoyuan Luo, Renxing Lu, Peishan Zhang, Wenting Zhang, Junai Pi, Jiang Zheng, Weixin Mai, Zesen Ding, Xiaowen Liu, Xinguang Ouyang, Suidong Huang, Gonghua Front Pharmacol Pharmacology Asthma is one of the most common chronic pulmonary disorders, affecting more than 330 million people worldwide. Unfortunately, there are still no specific treatments for asthma so far. Therefore, it is very important to develop effective therapeutics and medicines to deal with this intractable disease. Berberine (Ber) has fabulous anti-inflammatory and antibacterial effects, while its low water solubility and bioavailability greatly limit its curative efficiency. To improve the nasal mucosa absorption of poorly water-soluble drugs, such as Ber, we developed a platelet membrane- (PM-) coated nanoparticle (NP) system (PM@Ber-NPs) for targeted delivery of berberine to the inflammatory lungs. In vivo, PM@Ber-NPs exhibited enhanced targeting retention in the inflammatory lungs compared with free Ber. In a mouse model of house dust mite- (HDM-) induced asthma, PM@Ber-NPs markedly inhibited lung inflammation, as evident by reduced inflammatory cells and inflammatory cytokines in the lung compared with free Ber. Collectively, our study demonstrated the inhibitory actions of nasally delivered nanomedicines on HDM-induced asthma, primarily through regulating Th1/Th2 balance by enhancing IL-12 expression which could potentially reduce lung inflammation and allergic asthma. Frontiers Media S.A. 2021-11-09 /pmc/articles/PMC8630696/ /pubmed/34858170 http://dx.doi.org/10.3389/fphar.2021.724525 Text en Copyright © 2021 Jin, Li, Zhang, Luo, Lu, Zhang, Zhang, Pi, Zheng, Mai, Ding, Liu, Ouyang and Huang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Jin, Hua
Li, Jiale
Zhang, Miaoyuan
Luo, Renxing
Lu, Peishan
Zhang, Wenting
Zhang, Junai
Pi, Jiang
Zheng, Weixin
Mai, Zesen
Ding, Xiaowen
Liu, Xinguang
Ouyang, Suidong
Huang, Gonghua
Berberine-Loaded Biomimetic Nanoparticles Attenuate Inflammation of Experimental Allergic Asthma via Enhancing IL-12 Expression
title Berberine-Loaded Biomimetic Nanoparticles Attenuate Inflammation of Experimental Allergic Asthma via Enhancing IL-12 Expression
title_full Berberine-Loaded Biomimetic Nanoparticles Attenuate Inflammation of Experimental Allergic Asthma via Enhancing IL-12 Expression
title_fullStr Berberine-Loaded Biomimetic Nanoparticles Attenuate Inflammation of Experimental Allergic Asthma via Enhancing IL-12 Expression
title_full_unstemmed Berberine-Loaded Biomimetic Nanoparticles Attenuate Inflammation of Experimental Allergic Asthma via Enhancing IL-12 Expression
title_short Berberine-Loaded Biomimetic Nanoparticles Attenuate Inflammation of Experimental Allergic Asthma via Enhancing IL-12 Expression
title_sort berberine-loaded biomimetic nanoparticles attenuate inflammation of experimental allergic asthma via enhancing il-12 expression
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8630696/
https://www.ncbi.nlm.nih.gov/pubmed/34858170
http://dx.doi.org/10.3389/fphar.2021.724525
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