The Function of cGAS-STING Pathway in Treatment of Pancreatic Cancer

The activation of stimulator of interferon genes (STING) signalling pathway has been suggested to promote the immune responses against malignancy. STING is activated in response to the detection of cytosolic DNA and can induce type I interferons and link innate immunity with the adaptive immune syst...

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Autores principales: Mohseni, Ghazal, Li, Juan, Ariston Gabriel, Abakundana Nsenga, Du, Lutao, Wang, Yun-shan, Wang, Chuanxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8630697/
https://www.ncbi.nlm.nih.gov/pubmed/34858438
http://dx.doi.org/10.3389/fimmu.2021.781032
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author Mohseni, Ghazal
Li, Juan
Ariston Gabriel, Abakundana Nsenga
Du, Lutao
Wang, Yun-shan
Wang, Chuanxin
author_facet Mohseni, Ghazal
Li, Juan
Ariston Gabriel, Abakundana Nsenga
Du, Lutao
Wang, Yun-shan
Wang, Chuanxin
author_sort Mohseni, Ghazal
collection PubMed
description The activation of stimulator of interferon genes (STING) signalling pathway has been suggested to promote the immune responses against malignancy. STING is activated in response to the detection of cytosolic DNA and can induce type I interferons and link innate immunity with the adaptive immune system. Due to accretive evidence demonstrating that the STING pathway regulates the immune cells of the tumor microenvironment (TME), STING as a cancer biotherapy has attracted considerable attention. Pancreatic cancer, with a highly immunosuppressive TME, remains fatal cancer. STING has been applied to the treatment of pancreatic cancer through distinct strategies. This review reveals the role of STING signalling on pancreatic tumors and other diseases related to the pancreas. We then discuss new advances of STING in either monotherapy or combination methods for pancreatic cancer immunotherapy.
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spelling pubmed-86306972021-12-01 The Function of cGAS-STING Pathway in Treatment of Pancreatic Cancer Mohseni, Ghazal Li, Juan Ariston Gabriel, Abakundana Nsenga Du, Lutao Wang, Yun-shan Wang, Chuanxin Front Immunol Immunology The activation of stimulator of interferon genes (STING) signalling pathway has been suggested to promote the immune responses against malignancy. STING is activated in response to the detection of cytosolic DNA and can induce type I interferons and link innate immunity with the adaptive immune system. Due to accretive evidence demonstrating that the STING pathway regulates the immune cells of the tumor microenvironment (TME), STING as a cancer biotherapy has attracted considerable attention. Pancreatic cancer, with a highly immunosuppressive TME, remains fatal cancer. STING has been applied to the treatment of pancreatic cancer through distinct strategies. This review reveals the role of STING signalling on pancreatic tumors and other diseases related to the pancreas. We then discuss new advances of STING in either monotherapy or combination methods for pancreatic cancer immunotherapy. Frontiers Media S.A. 2021-11-09 /pmc/articles/PMC8630697/ /pubmed/34858438 http://dx.doi.org/10.3389/fimmu.2021.781032 Text en Copyright © 2021 Mohseni, Li, Ariston Gabriel, Du, Wang and Wang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Mohseni, Ghazal
Li, Juan
Ariston Gabriel, Abakundana Nsenga
Du, Lutao
Wang, Yun-shan
Wang, Chuanxin
The Function of cGAS-STING Pathway in Treatment of Pancreatic Cancer
title The Function of cGAS-STING Pathway in Treatment of Pancreatic Cancer
title_full The Function of cGAS-STING Pathway in Treatment of Pancreatic Cancer
title_fullStr The Function of cGAS-STING Pathway in Treatment of Pancreatic Cancer
title_full_unstemmed The Function of cGAS-STING Pathway in Treatment of Pancreatic Cancer
title_short The Function of cGAS-STING Pathway in Treatment of Pancreatic Cancer
title_sort function of cgas-sting pathway in treatment of pancreatic cancer
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8630697/
https://www.ncbi.nlm.nih.gov/pubmed/34858438
http://dx.doi.org/10.3389/fimmu.2021.781032
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