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The role of protein oxidation in the development of diabetic microvascular complications

OBJECTIVE: The role of protein oxidation in the development of diabetic microvascular complications was investigated. METHODS: In total, 266 participants were split into five groups: Group 1; diabetes mellitus for at least 10 years without any complications, Group 2; diabetic nephropathy, Group 3; d...

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Autores principales: Mertoglu, Cuma, Siranli, Gulsah, Coban, T. Abdulkadir, Karakurt, Yucel, Ersoy, Alevtina, Ozcicek, Adalet, Arslan, Yusuf, Gok, Gamze, Erel, Ozcan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Kare Publishing 2021
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8630725/
https://www.ncbi.nlm.nih.gov/pubmed/34909589
http://dx.doi.org/10.14744/nci.2021.33341
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author Mertoglu, Cuma
Siranli, Gulsah
Coban, T. Abdulkadir
Karakurt, Yucel
Ersoy, Alevtina
Ozcicek, Adalet
Arslan, Yusuf
Gok, Gamze
Erel, Ozcan
author_facet Mertoglu, Cuma
Siranli, Gulsah
Coban, T. Abdulkadir
Karakurt, Yucel
Ersoy, Alevtina
Ozcicek, Adalet
Arslan, Yusuf
Gok, Gamze
Erel, Ozcan
author_sort Mertoglu, Cuma
collection PubMed
description OBJECTIVE: The role of protein oxidation in the development of diabetic microvascular complications was investigated. METHODS: In total, 266 participants were split into five groups: Group 1; diabetes mellitus for at least 10 years without any complications, Group 2; diabetic nephropathy, Group 3; diabetic neuropathy, Group 4; diabetic retinopathy, and Group 5; control group. Thiol, disulfide, ferroxidase, and ischemia-modified albumin (IMA) levels were analyzed in the serum. RESULTS: Native thiol, total thiol, and native thiol/total thiol were lower in Group 4 than Groups 1, 3, and 5 (p<0.001). However, disulfide/native thiol and disulfide/total thiol were higher in Group 4 than all other groups (p<0.001). IMA was higher in Groups 3 and 4 than all other groups (p<0.001). Ferroxidase was lower in Groups 3 and 4 than Group 2 (p<0.001). CONCLUSION: Thiol-disulfide homeostasis impairment in favor of disulfide may have a function in the progress of diabetic retinopathy. Furthermore, the disruptions of IMA and ferroxidase levels involve in the development of diabetic retinopathy and neuropathy.
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spelling pubmed-86307252021-12-13 The role of protein oxidation in the development of diabetic microvascular complications Mertoglu, Cuma Siranli, Gulsah Coban, T. Abdulkadir Karakurt, Yucel Ersoy, Alevtina Ozcicek, Adalet Arslan, Yusuf Gok, Gamze Erel, Ozcan North Clin Istanb Original Article OBJECTIVE: The role of protein oxidation in the development of diabetic microvascular complications was investigated. METHODS: In total, 266 participants were split into five groups: Group 1; diabetes mellitus for at least 10 years without any complications, Group 2; diabetic nephropathy, Group 3; diabetic neuropathy, Group 4; diabetic retinopathy, and Group 5; control group. Thiol, disulfide, ferroxidase, and ischemia-modified albumin (IMA) levels were analyzed in the serum. RESULTS: Native thiol, total thiol, and native thiol/total thiol were lower in Group 4 than Groups 1, 3, and 5 (p<0.001). However, disulfide/native thiol and disulfide/total thiol were higher in Group 4 than all other groups (p<0.001). IMA was higher in Groups 3 and 4 than all other groups (p<0.001). Ferroxidase was lower in Groups 3 and 4 than Group 2 (p<0.001). CONCLUSION: Thiol-disulfide homeostasis impairment in favor of disulfide may have a function in the progress of diabetic retinopathy. Furthermore, the disruptions of IMA and ferroxidase levels involve in the development of diabetic retinopathy and neuropathy. Kare Publishing 2021-10-19 /pmc/articles/PMC8630725/ /pubmed/34909589 http://dx.doi.org/10.14744/nci.2021.33341 Text en Copyright: © 2021 by Istanbul Northern Anatolian Association of Public Hospitals https://creativecommons.org/licenses/by-nc-sa/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
spellingShingle Original Article
Mertoglu, Cuma
Siranli, Gulsah
Coban, T. Abdulkadir
Karakurt, Yucel
Ersoy, Alevtina
Ozcicek, Adalet
Arslan, Yusuf
Gok, Gamze
Erel, Ozcan
The role of protein oxidation in the development of diabetic microvascular complications
title The role of protein oxidation in the development of diabetic microvascular complications
title_full The role of protein oxidation in the development of diabetic microvascular complications
title_fullStr The role of protein oxidation in the development of diabetic microvascular complications
title_full_unstemmed The role of protein oxidation in the development of diabetic microvascular complications
title_short The role of protein oxidation in the development of diabetic microvascular complications
title_sort role of protein oxidation in the development of diabetic microvascular complications
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8630725/
https://www.ncbi.nlm.nih.gov/pubmed/34909589
http://dx.doi.org/10.14744/nci.2021.33341
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