Rearrangement-mediated cis-regulatory alterations in advanced patient tumors reveal interactions with therapy

The global impact of somatic structural variants (SVs) on gene regulation in advanced tumors with complex treatment histories has been mostly uncharacterized. Here, using whole-genome and RNA sequencing from 570 recurrent or metastatic tumors, we report the altered expression of hundreds of genes in...

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Detalles Bibliográficos
Autores principales: Zhang, Yiqun, Chen, Fengju, Pleasance, Erin, Williamson, Laura, Grisdale, Cameron J., Titmuss, Emma, Laskin, Janessa, Jones, Steven J.M., Cortes-Ciriano, Isidro, Marra, Marco A., Creighton, Chad J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8630779/
https://www.ncbi.nlm.nih.gov/pubmed/34788622
http://dx.doi.org/10.1016/j.celrep.2021.110023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8630779/
https://www.ncbi.nlm.nih.gov/pubmed/34788622
http://dx.doi.org/10.1016/j.celrep.2021.110023

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