Cargando…

Rearrangement-mediated cis-regulatory alterations in advanced patient tumors reveal interactions with therapy

The global impact of somatic structural variants (SVs) on gene regulation in advanced tumors with complex treatment histories has been mostly uncharacterized. Here, using whole-genome and RNA sequencing from 570 recurrent or metastatic tumors, we report the altered expression of hundreds of genes in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Yiqun, Chen, Fengju, Pleasance, Erin, Williamson, Laura, Grisdale, Cameron J., Titmuss, Emma, Laskin, Janessa, Jones, Steven J.M., Cortes-Ciriano, Isidro, Marra, Marco A., Creighton, Chad J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8630779/ https://www.ncbi.nlm.nih.gov/pubmed/34788622 http://dx.doi.org/10.1016/j.celrep.2021.110023

Ejemplares similares

High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations
por: Zhang, Yiqun, et al.
Publicado: (2020)

Author Correction: High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations
por: Zhang, Yiqun, et al.
Publicado: (2022)

TMBur: a distributable tumor mutation burden approach for whole genome sequencing
por: Titmuss, Emma, et al.
Publicado: (2022)

A pediatric brain tumor atlas of genes deregulated by somatic genomic rearrangement
por: Zhang, Yiqun, et al.
Publicado: (2021)

SVExpress: identifying gene features altered recurrently in expression with nearby structural variant breakpoints
por: Zhang, Yiqun, et al.
Publicado: (2021)

Systematic identification of non-coding somatic single nucleotide variants associated with altered transcription and DNA methylation in adult and pediatric cancers
por: Chen, Fengju, et al.
Publicado: (2021)

Pan-cancer molecular subtypes of metastasis reveal distinct and evolving transcriptional programs
por: Zhang, Yiqun, et al.
Publicado: (2023)

Fluorouracil sensitivity in a head and neck squamous cell carcinoma with a somatic DPYD structural variant
por: Majounie, Elisa, et al.
Publicado: (2020)

The pivotal role of sampling recurrent tumors in the precision care of patients with tumors of the central nervous system
por: Wong, Derek, et al.
Publicado: (2019)

Homologous recombination deficiency signatures in gastrointestinal and thoracic cancers correlate with platinum therapy duration
por: Tsang, Erica S., et al.
Publicado: (2023)

Clinical and cost outcomes following genomics‐informed treatment for advanced cancers
por: Weymann, Deirdre, et al.
Publicado: (2021)

Proteogenomic characterization of 2002 human cancers reveals pan-cancer molecular subtypes and associated pathways
por: Zhang, Yiqun, et al.
Publicado: (2022)

Author Correction: Proteogenomic characterization of 2002 human cancers reveals pan-cancer molecular subtypes and associated pathways
por: Zhang, Yiqun, et al.
Publicado: (2022)

Global impact of somatic structural variation on the cancer proteome
por: Chen, Fengju, et al.
Publicado: (2023)

Bioalerts: a python library for the derivation of structural alerts from bioactivity and toxicity data sets
por: Cortes-Ciriano, Isidro
Publicado: (2016)

Meta-analysis of host transcriptional responses to SARS-CoV-2 infection reveals their manifestation in human tumors
por: Chen, Fengju, et al.
Publicado: (2021)

Clinical response to nivolumab in an INI1-deficient pediatric chordoma correlates with immunogenic recognition of brachyury
por: Williamson, Laura M., et al.
Publicado: (2021)

The Molecular Mechanism of a Cis-Regulatory Adaptation in Yeast
por: Chang, Jessica, et al.
Publicado: (2013)

Genomics of chromophobe renal cell carcinoma: implications from a rare tumor for pan-cancer studies
por: Rathmell, Kimryn W., et al.
Publicado: (2015)

Non-homologous end joining shapes the genomic rearrangement landscape of chromothripsis from mitotic errors
por: Hu, Qing, et al.
Publicado: (2023)

Whole-genome and transcriptome analysis of advanced adrenocortical cancer highlights multiple alterations affecting epigenome and DNA repair pathways
por: Lavoie, Jean-Michel, et al.
Publicado: (2022)

KekuleScope: prediction of cancer cell line sensitivity and compound potency using convolutional neural networks trained on compound images
por: Cortés-Ciriano, Isidro, et al.
Publicado: (2019)

Artificial intelligence in drug discovery: what is realistic, what are illusions? Part 2: a discussion of chemical and biological data
por: Bender, Andreas, et al.
Publicado: (2021)

Establishing a Framework for the Clinical Translation of Germline Findings in Precision Oncology
por: Dixon, Katherine, et al.
Publicado: (2020)

OncoCis: annotation of cis-regulatory mutations in cancer
por: Perera, Dilmi, et al.
Publicado: (2014)

Chemokine expression predicts T cell-inflammation and improved survival with checkpoint inhibition across solid cancers
por: Romero, Joan Miguel, et al.
Publicado: (2023)

NTRK2 Fusion driven pediatric glioblastoma: Identification of oncogenic Drivers via integrative Genome and transcriptome profiling
por: Britton, Heidi M., et al.
Publicado: (2021)

Pan-cancer molecular subtypes revealed by mass-spectrometry-based proteomic characterization of more than 500 human cancers
por: Chen, Fengju, et al.
Publicado: (2019)

Clinical outcomes after whole-genome sequencing in patients with metastatic non-small-cell lung cancer
por: Tsang, Erica S., et al.
Publicado: (2019)

Molecular etiology of an indolent lymphoproliferative disorder determined by whole-genome sequencing
por: Parker, Jeremy D.K., et al.
Publicado: (2016)

Personalized oncogenomic analysis of metastatic adenoid cystic carcinoma: using whole-genome sequencing to inform clinical decision-making
por: Chahal, Manik, et al.
Publicado: (2018)

A platform for oncogenomic reporting and interpretation
por: Reisle, Caralyn, et al.
Publicado: (2022)

cisRED: a database system for genome-scale computational discovery of regulatory elements
por: Robertson, G., et al.
Publicado: (2006)

Spatially varying cis-regulatory divergence in Drosophila embryos elucidates cis-regulatory logic
por: Combs, Peter A., et al.
Publicado: (2018)

Identification of cis-Regulatory Elements in the dmyc Gene of Drosophila Melanogaster
por: Kharazmi, Jasmine, et al.
Publicado: (2011)

A semi-supervised learning framework for quantitative structure–activity regression modelling
por: Watson, Oliver, et al.
Publicado: (2020)

High-throughput discovery of post-transcriptional cis-regulatory elements
por: Wissink, Erin M., et al.
Publicado: (2016)

Global molecular alterations involving recurrence or progression of pediatric brain tumors
por: Chen, Fengju, et al.
Publicado: (2021)

i-cisTarget: an integrative genomics method for the prediction of regulatory features and cis-regulatory modules
por: Herrmann, Carl, et al.
Publicado: (2012)

A cis-regulatory module activating transcription in the suspensor contains five cis-regulatory elements
por: Henry, Kelli F., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_7t16tl7d1isunonrcro8ue8du4