Direct molecular evidence for both multicentric and monoclonal carcinogenesis followed by transdifferentiation from hepatocellular carcinoma to cholangiocarcinoma in a case of metachronous liver cancer

Frequent recurrence is a major issue in liver cancer and histological heterogeneity frequently occurs in this cancer type. However, it has remained elusive whether such cancers are multicentric or monoclonal. To elucidate the clonal evolution of hepatocellular carcinoma (HCC) recurrence and combined...

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Detalles Bibliográficos
Autores principales: Ohni, Sumie, Yamaguchi, Hiromi, Hirotani, Yukari, Nakanishi, Yoko, Midorikawa, Yutaka, Sugitani, Masahiko, Naruse, Hiromu, Nakayama, Tomohiro, Makishima, Makoto, Esumi, Mariko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8630812/
https://www.ncbi.nlm.nih.gov/pubmed/34868359
http://dx.doi.org/10.3892/ol.2021.13140

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