Cargando…

A hospital-wide outbreak of IMI-17-producing Enterobacter ludwigii in an Israeli hospital

BACKGROUND: To describe the course and intervention of an hospital-wide IMI-Producing Enterobacter ludwigii outbreak. METHODS: This was an outbreak interventional study, done at a tertiary care center in Tel-Aviv, Israel. Data was collected on the course of the outbreak and the demographic and clini...

Descripción completa

Detalles Bibliográficos
Autores principales: Schechner, Vered, Levytskyi, Katya, Shalom, Ohad, Yalek, Alexander, Adler, Amos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8630898/
https://www.ncbi.nlm.nih.gov/pubmed/34844659
http://dx.doi.org/10.1186/s13756-021-01036-0
_version_ 1784607452391538688
author Schechner, Vered
Levytskyi, Katya
Shalom, Ohad
Yalek, Alexander
Adler, Amos
author_facet Schechner, Vered
Levytskyi, Katya
Shalom, Ohad
Yalek, Alexander
Adler, Amos
author_sort Schechner, Vered
collection PubMed
description BACKGROUND: To describe the course and intervention of an hospital-wide IMI-Producing Enterobacter ludwigii outbreak. METHODS: This was an outbreak interventional study, done at a tertiary care center in Tel-Aviv, Israel. Data was collected on the course of the outbreak and the demographic and clinical characteristics of all patients involved in the outbreak. The intervention measures included patients’ cohorting, contact isolation precautions, environmental cleaning and screening of contacts. The molecular features and phylogeny of outbreak-related isolates were studied by whole-genome based analysis. RESULTS: The outbreak included 34 patients that were colonized by IMI-Producing E. ludwigii and were identified in 24 wards throughout the hospital. Colonization was identified in the first 72 h of admission in 13/34 patients (38.2%). Most patients (91.2%) were admitted from home and had relatively low level of comorbidities. The majority of them (88%) had no recent use of invasive catheters and none had previous carriage of other multi-drug resistant bacteria. All available isolates harbored the bla(IMI-17) allele and belonged to Sequence-Type 385. With the exception of two isolates, all isolates were closely related with less than a 20-SNP difference between them. CONCLUSIONS: This outbreak had most likely originated in the community and subsequently disseminated inside our institution. More studies are required in order to elucidate the epidemiology of IMI-Producing E. ludwigii and the possible role of environmental sources in its dissemination.
format Online
Article
Text
id pubmed-8630898
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-86308982021-12-01 A hospital-wide outbreak of IMI-17-producing Enterobacter ludwigii in an Israeli hospital Schechner, Vered Levytskyi, Katya Shalom, Ohad Yalek, Alexander Adler, Amos Antimicrob Resist Infect Control Research BACKGROUND: To describe the course and intervention of an hospital-wide IMI-Producing Enterobacter ludwigii outbreak. METHODS: This was an outbreak interventional study, done at a tertiary care center in Tel-Aviv, Israel. Data was collected on the course of the outbreak and the demographic and clinical characteristics of all patients involved in the outbreak. The intervention measures included patients’ cohorting, contact isolation precautions, environmental cleaning and screening of contacts. The molecular features and phylogeny of outbreak-related isolates were studied by whole-genome based analysis. RESULTS: The outbreak included 34 patients that were colonized by IMI-Producing E. ludwigii and were identified in 24 wards throughout the hospital. Colonization was identified in the first 72 h of admission in 13/34 patients (38.2%). Most patients (91.2%) were admitted from home and had relatively low level of comorbidities. The majority of them (88%) had no recent use of invasive catheters and none had previous carriage of other multi-drug resistant bacteria. All available isolates harbored the bla(IMI-17) allele and belonged to Sequence-Type 385. With the exception of two isolates, all isolates were closely related with less than a 20-SNP difference between them. CONCLUSIONS: This outbreak had most likely originated in the community and subsequently disseminated inside our institution. More studies are required in order to elucidate the epidemiology of IMI-Producing E. ludwigii and the possible role of environmental sources in its dissemination. BioMed Central 2021-11-29 /pmc/articles/PMC8630898/ /pubmed/34844659 http://dx.doi.org/10.1186/s13756-021-01036-0 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Schechner, Vered
Levytskyi, Katya
Shalom, Ohad
Yalek, Alexander
Adler, Amos
A hospital-wide outbreak of IMI-17-producing Enterobacter ludwigii in an Israeli hospital
title A hospital-wide outbreak of IMI-17-producing Enterobacter ludwigii in an Israeli hospital
title_full A hospital-wide outbreak of IMI-17-producing Enterobacter ludwigii in an Israeli hospital
title_fullStr A hospital-wide outbreak of IMI-17-producing Enterobacter ludwigii in an Israeli hospital
title_full_unstemmed A hospital-wide outbreak of IMI-17-producing Enterobacter ludwigii in an Israeli hospital
title_short A hospital-wide outbreak of IMI-17-producing Enterobacter ludwigii in an Israeli hospital
title_sort hospital-wide outbreak of imi-17-producing enterobacter ludwigii in an israeli hospital
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8630898/
https://www.ncbi.nlm.nih.gov/pubmed/34844659
http://dx.doi.org/10.1186/s13756-021-01036-0
work_keys_str_mv AT schechnervered ahospitalwideoutbreakofimi17producingenterobacterludwigiiinanisraelihospital
AT levytskyikatya ahospitalwideoutbreakofimi17producingenterobacterludwigiiinanisraelihospital
AT shalomohad ahospitalwideoutbreakofimi17producingenterobacterludwigiiinanisraelihospital
AT yalekalexander ahospitalwideoutbreakofimi17producingenterobacterludwigiiinanisraelihospital
AT adleramos ahospitalwideoutbreakofimi17producingenterobacterludwigiiinanisraelihospital
AT schechnervered hospitalwideoutbreakofimi17producingenterobacterludwigiiinanisraelihospital
AT levytskyikatya hospitalwideoutbreakofimi17producingenterobacterludwigiiinanisraelihospital
AT shalomohad hospitalwideoutbreakofimi17producingenterobacterludwigiiinanisraelihospital
AT yalekalexander hospitalwideoutbreakofimi17producingenterobacterludwigiiinanisraelihospital
AT adleramos hospitalwideoutbreakofimi17producingenterobacterludwigiiinanisraelihospital