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Effects of Dietary Zinc Sources on Growth Performance and Gut Health of Weaned Piglets

The present study aimed to investigate the effects of dietary zinc sources on the growth performance and gut health of weaned piglets. In total, 96 Duroc × Landrace × Yorkshire (DLY) weaned piglets with an initial average body weight of 8.81±0.42kg were divided into four groups, with six replicates...

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Autores principales: Diao, Hui, Yan, Jiayou, Li, Shuwei, Kuang, Shengyao, Wei, Xiaolan, Zhou, Mengjia, Zhang, Jinxiu, Huang, Chongbo, He, Peng, Tang, Wenjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8631109/
https://www.ncbi.nlm.nih.gov/pubmed/34858378
http://dx.doi.org/10.3389/fmicb.2021.771617
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author Diao, Hui
Yan, Jiayou
Li, Shuwei
Kuang, Shengyao
Wei, Xiaolan
Zhou, Mengjia
Zhang, Jinxiu
Huang, Chongbo
He, Peng
Tang, Wenjie
author_facet Diao, Hui
Yan, Jiayou
Li, Shuwei
Kuang, Shengyao
Wei, Xiaolan
Zhou, Mengjia
Zhang, Jinxiu
Huang, Chongbo
He, Peng
Tang, Wenjie
author_sort Diao, Hui
collection PubMed
description The present study aimed to investigate the effects of dietary zinc sources on the growth performance and gut health of weaned piglets. In total, 96 Duroc × Landrace × Yorkshire (DLY) weaned piglets with an initial average body weight of 8.81±0.42kg were divided into four groups, with six replicates per treatment and four pigs per replicate. The dietary treatment groups were as follows: (1) control group, basal diet; (2) zinc sulphate (ZnSO4) group, basal diet +100mg/kg ZnSO4; (3) glycine zinc (Gly-Zn) group, basal diet +100mg/kg Gly-Zn and (4) zinc lactate group, and basal diet +100mg/kg zinc lactate. The whole trial lasted for 28days. Decreased F/G was noted in the Gly-Zn and zinc lactate groups (p<0.05). The zinc lactate group had a lower diarrhea rate than the control group (p<0.05). Moreover, the ZnSO4, Gly-Zn, and zinc lactate groups had significantly higher apparent total tract digestibility of dry matter (DM), crude protein (CP), ether extract (EE), crude ash, and zinc than the control group (p<0.05). The Gly-Zn and zinc lactate groups had higher jejunal villus height and a higher villus height:crypt depth ratio than the control group (p<0.05). In addition, the ZnSO4, Gly-Zn and zinc lactate groups had a significantly lower mRNA expression level of jejunal ZRT/IRT-like protein 4 (ZIP4) and higher mRNA expression level of jejunal interleukin-1β (IL-1β) than the control group (p<0.05). The mRNA expression level of jejunal zinc transporter 2 (ZNT2) was higher and that of jejunal Bcl-2-associated X protein (Bax) was lower in the Gly-Zn and zinc lactate groups than in the control group (p<0.05). Moreover, the zinc lactate group had a higher count of Lactobacillus spp. in the cecal digesta and higher mRNA expression levels of jejunal occludin and mucin 2 (MUC2) than the control group (p<0.05). In conclusion, dietary supplementation with 100mg/kg ZnSO4, Gly-Zn, or zinc lactate could improve the growth performance and gut barrier function of weaned piglets. Dietary supplementation with organic zinc, particularly zinc lactate, had the best effect.
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spelling pubmed-86311092021-12-01 Effects of Dietary Zinc Sources on Growth Performance and Gut Health of Weaned Piglets Diao, Hui Yan, Jiayou Li, Shuwei Kuang, Shengyao Wei, Xiaolan Zhou, Mengjia Zhang, Jinxiu Huang, Chongbo He, Peng Tang, Wenjie Front Microbiol Microbiology The present study aimed to investigate the effects of dietary zinc sources on the growth performance and gut health of weaned piglets. In total, 96 Duroc × Landrace × Yorkshire (DLY) weaned piglets with an initial average body weight of 8.81±0.42kg were divided into four groups, with six replicates per treatment and four pigs per replicate. The dietary treatment groups were as follows: (1) control group, basal diet; (2) zinc sulphate (ZnSO4) group, basal diet +100mg/kg ZnSO4; (3) glycine zinc (Gly-Zn) group, basal diet +100mg/kg Gly-Zn and (4) zinc lactate group, and basal diet +100mg/kg zinc lactate. The whole trial lasted for 28days. Decreased F/G was noted in the Gly-Zn and zinc lactate groups (p<0.05). The zinc lactate group had a lower diarrhea rate than the control group (p<0.05). Moreover, the ZnSO4, Gly-Zn, and zinc lactate groups had significantly higher apparent total tract digestibility of dry matter (DM), crude protein (CP), ether extract (EE), crude ash, and zinc than the control group (p<0.05). The Gly-Zn and zinc lactate groups had higher jejunal villus height and a higher villus height:crypt depth ratio than the control group (p<0.05). In addition, the ZnSO4, Gly-Zn and zinc lactate groups had a significantly lower mRNA expression level of jejunal ZRT/IRT-like protein 4 (ZIP4) and higher mRNA expression level of jejunal interleukin-1β (IL-1β) than the control group (p<0.05). The mRNA expression level of jejunal zinc transporter 2 (ZNT2) was higher and that of jejunal Bcl-2-associated X protein (Bax) was lower in the Gly-Zn and zinc lactate groups than in the control group (p<0.05). Moreover, the zinc lactate group had a higher count of Lactobacillus spp. in the cecal digesta and higher mRNA expression levels of jejunal occludin and mucin 2 (MUC2) than the control group (p<0.05). In conclusion, dietary supplementation with 100mg/kg ZnSO4, Gly-Zn, or zinc lactate could improve the growth performance and gut barrier function of weaned piglets. Dietary supplementation with organic zinc, particularly zinc lactate, had the best effect. Frontiers Media S.A. 2021-10-28 /pmc/articles/PMC8631109/ /pubmed/34858378 http://dx.doi.org/10.3389/fmicb.2021.771617 Text en Copyright © 2021 Diao, Yan, Li, Kuang, Wei, Zhou, Zhang, Huang, He and Tang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Diao, Hui
Yan, Jiayou
Li, Shuwei
Kuang, Shengyao
Wei, Xiaolan
Zhou, Mengjia
Zhang, Jinxiu
Huang, Chongbo
He, Peng
Tang, Wenjie
Effects of Dietary Zinc Sources on Growth Performance and Gut Health of Weaned Piglets
title Effects of Dietary Zinc Sources on Growth Performance and Gut Health of Weaned Piglets
title_full Effects of Dietary Zinc Sources on Growth Performance and Gut Health of Weaned Piglets
title_fullStr Effects of Dietary Zinc Sources on Growth Performance and Gut Health of Weaned Piglets
title_full_unstemmed Effects of Dietary Zinc Sources on Growth Performance and Gut Health of Weaned Piglets
title_short Effects of Dietary Zinc Sources on Growth Performance and Gut Health of Weaned Piglets
title_sort effects of dietary zinc sources on growth performance and gut health of weaned piglets
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8631109/
https://www.ncbi.nlm.nih.gov/pubmed/34858378
http://dx.doi.org/10.3389/fmicb.2021.771617
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