Large Multicohort Study Reveals a Prostate Cancer Susceptibility Allele at 5p15 Regulating TERT via Androgen Signaling-Orchestrated Chromatin Binding of E2F1 and MYC

Aberrant telomerase reverse transcriptase (TERT) expression is crucial for tumor survival and cancer cells escaping apoptosis. Multiple TERT-locus variants at 5p15 have been discovered in association with cancer risk, yet the underlying mechanisms and clinical impacts remain unclear. Here, our assoc...

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Detalles Bibliográficos
Autores principales: Dong, Xiaoming, Zhang, Qin, Hao, Jinglan, Xie, Qianwen, Xu, Binbing, Zhang, Peng, Lu, Haicheng, Huang, Qilai, Yang, Tielin, Wei, Gong-Hong, Na, Rong, Gao, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8631195/
https://www.ncbi.nlm.nih.gov/pubmed/34858826
http://dx.doi.org/10.3389/fonc.2021.754206

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