Cargando…

The Identification of a Tumor Infiltration CD8+ T-Cell Gene Signature That Can Potentially Improve the Prognosis and Prediction of Immunization Responses in Papillary Renal Cell Carcinoma

BACKGROUND: CD8+ T cells, vital effectors pertaining to adaptive immunity, display close relationships to the immunization responses to kill tumor cells. Understanding the effect exerted by tumor infiltration CD8+ T cells in papillary renal cell carcinoma (papRCC) is critical for assessing the progn...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Jie, Huang, Meiying, Huang, Peng, Zhao, Jingjie, Tan, Junhua, Huang, Feifan, Ma, Ruiying, Xiao, Yu, Deng, Gao, Wei, Liuzhi, Wei, Qiuju, Wang, Zechen, He, Siyuan, Shen, Jiajia, Sooranna, Suren, Meng, Lingzhang, Song, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8631402/
https://www.ncbi.nlm.nih.gov/pubmed/34858833
http://dx.doi.org/10.3389/fonc.2021.757641
_version_ 1784607553998553088
author Wang, Jie
Huang, Meiying
Huang, Peng
Zhao, Jingjie
Tan, Junhua
Huang, Feifan
Ma, Ruiying
Xiao, Yu
Deng, Gao
Wei, Liuzhi
Wei, Qiuju
Wang, Zechen
He, Siyuan
Shen, Jiajia
Sooranna, Suren
Meng, Lingzhang
Song, Jian
author_facet Wang, Jie
Huang, Meiying
Huang, Peng
Zhao, Jingjie
Tan, Junhua
Huang, Feifan
Ma, Ruiying
Xiao, Yu
Deng, Gao
Wei, Liuzhi
Wei, Qiuju
Wang, Zechen
He, Siyuan
Shen, Jiajia
Sooranna, Suren
Meng, Lingzhang
Song, Jian
author_sort Wang, Jie
collection PubMed
description BACKGROUND: CD8+ T cells, vital effectors pertaining to adaptive immunity, display close relationships to the immunization responses to kill tumor cells. Understanding the effect exerted by tumor infiltration CD8+ T cells in papillary renal cell carcinoma (papRCC) is critical for assessing the prognosis process and responses to immunization therapy in cases with this disease. MATERIALS AND APPROACHES: The single-cell transcriptome data of papRCC were used for screening CD8+ T-cell-correlated differentially expressed genes to achieve the following investigations. On that basis, a prognosis gene signature associated with tumor infiltration CD8+ T cell was built and verified with The Cancer Genome Atlas data set. Risk scores were determined for papRCC cases and categorized as high- or low-risk groups. The prognosis significance for risk scores was assessed with multiple-variate Cox investigation and Kaplan–Meier survival curves. In addition, the possible capability exhibited by the genetic profiles of cases to assess the response to immunization therapy was further explored. RESULTS: Six hundred twenty-one cell death-inhibiting RNA genes were screened using single-cell RNA sequencing. A gene signature consisting of seven genes (LYAR, YBX1, PNRC1, TCF25, MYL12B, MINOS1, and LINC01420) was then identified, and this collective was considered to be an independent prognosis indicator that could strongly assess overall survival in papRCC. In addition, the data allowed papRCC cases to fall to cohorts at high and low risks, exhibiting a wide range of clinically related features as well as different CD8+ T-cell immunization infiltration and immunization therapy responses. CONCLUSIONS: Our work provides a possible explanation for the limited response of current immunization checkpoint-inhibiting elements for combating papRCC. Furthermore, the researchers built a novel genetic signature that was able to assess the prognosis and immunotherapeutic response of cases. This may also be considered as a promising therapeutic target for the disease.
format Online
Article
Text
id pubmed-8631402
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-86314022021-12-01 The Identification of a Tumor Infiltration CD8+ T-Cell Gene Signature That Can Potentially Improve the Prognosis and Prediction of Immunization Responses in Papillary Renal Cell Carcinoma Wang, Jie Huang, Meiying Huang, Peng Zhao, Jingjie Tan, Junhua Huang, Feifan Ma, Ruiying Xiao, Yu Deng, Gao Wei, Liuzhi Wei, Qiuju Wang, Zechen He, Siyuan Shen, Jiajia Sooranna, Suren Meng, Lingzhang Song, Jian Front Oncol Oncology BACKGROUND: CD8+ T cells, vital effectors pertaining to adaptive immunity, display close relationships to the immunization responses to kill tumor cells. Understanding the effect exerted by tumor infiltration CD8+ T cells in papillary renal cell carcinoma (papRCC) is critical for assessing the prognosis process and responses to immunization therapy in cases with this disease. MATERIALS AND APPROACHES: The single-cell transcriptome data of papRCC were used for screening CD8+ T-cell-correlated differentially expressed genes to achieve the following investigations. On that basis, a prognosis gene signature associated with tumor infiltration CD8+ T cell was built and verified with The Cancer Genome Atlas data set. Risk scores were determined for papRCC cases and categorized as high- or low-risk groups. The prognosis significance for risk scores was assessed with multiple-variate Cox investigation and Kaplan–Meier survival curves. In addition, the possible capability exhibited by the genetic profiles of cases to assess the response to immunization therapy was further explored. RESULTS: Six hundred twenty-one cell death-inhibiting RNA genes were screened using single-cell RNA sequencing. A gene signature consisting of seven genes (LYAR, YBX1, PNRC1, TCF25, MYL12B, MINOS1, and LINC01420) was then identified, and this collective was considered to be an independent prognosis indicator that could strongly assess overall survival in papRCC. In addition, the data allowed papRCC cases to fall to cohorts at high and low risks, exhibiting a wide range of clinically related features as well as different CD8+ T-cell immunization infiltration and immunization therapy responses. CONCLUSIONS: Our work provides a possible explanation for the limited response of current immunization checkpoint-inhibiting elements for combating papRCC. Furthermore, the researchers built a novel genetic signature that was able to assess the prognosis and immunotherapeutic response of cases. This may also be considered as a promising therapeutic target for the disease. Frontiers Media S.A. 2021-11-10 /pmc/articles/PMC8631402/ /pubmed/34858833 http://dx.doi.org/10.3389/fonc.2021.757641 Text en Copyright © 2021 Wang, Huang, Huang, Zhao, Tan, Huang, Ma, Xiao, Deng, Wei, Wei, Wang, He, Shen, Sooranna, Meng and Song https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Wang, Jie
Huang, Meiying
Huang, Peng
Zhao, Jingjie
Tan, Junhua
Huang, Feifan
Ma, Ruiying
Xiao, Yu
Deng, Gao
Wei, Liuzhi
Wei, Qiuju
Wang, Zechen
He, Siyuan
Shen, Jiajia
Sooranna, Suren
Meng, Lingzhang
Song, Jian
The Identification of a Tumor Infiltration CD8+ T-Cell Gene Signature That Can Potentially Improve the Prognosis and Prediction of Immunization Responses in Papillary Renal Cell Carcinoma
title The Identification of a Tumor Infiltration CD8+ T-Cell Gene Signature That Can Potentially Improve the Prognosis and Prediction of Immunization Responses in Papillary Renal Cell Carcinoma
title_full The Identification of a Tumor Infiltration CD8+ T-Cell Gene Signature That Can Potentially Improve the Prognosis and Prediction of Immunization Responses in Papillary Renal Cell Carcinoma
title_fullStr The Identification of a Tumor Infiltration CD8+ T-Cell Gene Signature That Can Potentially Improve the Prognosis and Prediction of Immunization Responses in Papillary Renal Cell Carcinoma
title_full_unstemmed The Identification of a Tumor Infiltration CD8+ T-Cell Gene Signature That Can Potentially Improve the Prognosis and Prediction of Immunization Responses in Papillary Renal Cell Carcinoma
title_short The Identification of a Tumor Infiltration CD8+ T-Cell Gene Signature That Can Potentially Improve the Prognosis and Prediction of Immunization Responses in Papillary Renal Cell Carcinoma
title_sort identification of a tumor infiltration cd8+ t-cell gene signature that can potentially improve the prognosis and prediction of immunization responses in papillary renal cell carcinoma
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8631402/
https://www.ncbi.nlm.nih.gov/pubmed/34858833
http://dx.doi.org/10.3389/fonc.2021.757641
work_keys_str_mv AT wangjie theidentificationofatumorinfiltrationcd8tcellgenesignaturethatcanpotentiallyimprovetheprognosisandpredictionofimmunizationresponsesinpapillaryrenalcellcarcinoma
AT huangmeiying theidentificationofatumorinfiltrationcd8tcellgenesignaturethatcanpotentiallyimprovetheprognosisandpredictionofimmunizationresponsesinpapillaryrenalcellcarcinoma
AT huangpeng theidentificationofatumorinfiltrationcd8tcellgenesignaturethatcanpotentiallyimprovetheprognosisandpredictionofimmunizationresponsesinpapillaryrenalcellcarcinoma
AT zhaojingjie theidentificationofatumorinfiltrationcd8tcellgenesignaturethatcanpotentiallyimprovetheprognosisandpredictionofimmunizationresponsesinpapillaryrenalcellcarcinoma
AT tanjunhua theidentificationofatumorinfiltrationcd8tcellgenesignaturethatcanpotentiallyimprovetheprognosisandpredictionofimmunizationresponsesinpapillaryrenalcellcarcinoma
AT huangfeifan theidentificationofatumorinfiltrationcd8tcellgenesignaturethatcanpotentiallyimprovetheprognosisandpredictionofimmunizationresponsesinpapillaryrenalcellcarcinoma
AT maruiying theidentificationofatumorinfiltrationcd8tcellgenesignaturethatcanpotentiallyimprovetheprognosisandpredictionofimmunizationresponsesinpapillaryrenalcellcarcinoma
AT xiaoyu theidentificationofatumorinfiltrationcd8tcellgenesignaturethatcanpotentiallyimprovetheprognosisandpredictionofimmunizationresponsesinpapillaryrenalcellcarcinoma
AT denggao theidentificationofatumorinfiltrationcd8tcellgenesignaturethatcanpotentiallyimprovetheprognosisandpredictionofimmunizationresponsesinpapillaryrenalcellcarcinoma
AT weiliuzhi theidentificationofatumorinfiltrationcd8tcellgenesignaturethatcanpotentiallyimprovetheprognosisandpredictionofimmunizationresponsesinpapillaryrenalcellcarcinoma
AT weiqiuju theidentificationofatumorinfiltrationcd8tcellgenesignaturethatcanpotentiallyimprovetheprognosisandpredictionofimmunizationresponsesinpapillaryrenalcellcarcinoma
AT wangzechen theidentificationofatumorinfiltrationcd8tcellgenesignaturethatcanpotentiallyimprovetheprognosisandpredictionofimmunizationresponsesinpapillaryrenalcellcarcinoma
AT hesiyuan theidentificationofatumorinfiltrationcd8tcellgenesignaturethatcanpotentiallyimprovetheprognosisandpredictionofimmunizationresponsesinpapillaryrenalcellcarcinoma
AT shenjiajia theidentificationofatumorinfiltrationcd8tcellgenesignaturethatcanpotentiallyimprovetheprognosisandpredictionofimmunizationresponsesinpapillaryrenalcellcarcinoma
AT soorannasuren theidentificationofatumorinfiltrationcd8tcellgenesignaturethatcanpotentiallyimprovetheprognosisandpredictionofimmunizationresponsesinpapillaryrenalcellcarcinoma
AT menglingzhang theidentificationofatumorinfiltrationcd8tcellgenesignaturethatcanpotentiallyimprovetheprognosisandpredictionofimmunizationresponsesinpapillaryrenalcellcarcinoma
AT songjian theidentificationofatumorinfiltrationcd8tcellgenesignaturethatcanpotentiallyimprovetheprognosisandpredictionofimmunizationresponsesinpapillaryrenalcellcarcinoma
AT wangjie identificationofatumorinfiltrationcd8tcellgenesignaturethatcanpotentiallyimprovetheprognosisandpredictionofimmunizationresponsesinpapillaryrenalcellcarcinoma
AT huangmeiying identificationofatumorinfiltrationcd8tcellgenesignaturethatcanpotentiallyimprovetheprognosisandpredictionofimmunizationresponsesinpapillaryrenalcellcarcinoma
AT huangpeng identificationofatumorinfiltrationcd8tcellgenesignaturethatcanpotentiallyimprovetheprognosisandpredictionofimmunizationresponsesinpapillaryrenalcellcarcinoma
AT zhaojingjie identificationofatumorinfiltrationcd8tcellgenesignaturethatcanpotentiallyimprovetheprognosisandpredictionofimmunizationresponsesinpapillaryrenalcellcarcinoma
AT tanjunhua identificationofatumorinfiltrationcd8tcellgenesignaturethatcanpotentiallyimprovetheprognosisandpredictionofimmunizationresponsesinpapillaryrenalcellcarcinoma
AT huangfeifan identificationofatumorinfiltrationcd8tcellgenesignaturethatcanpotentiallyimprovetheprognosisandpredictionofimmunizationresponsesinpapillaryrenalcellcarcinoma
AT maruiying identificationofatumorinfiltrationcd8tcellgenesignaturethatcanpotentiallyimprovetheprognosisandpredictionofimmunizationresponsesinpapillaryrenalcellcarcinoma
AT xiaoyu identificationofatumorinfiltrationcd8tcellgenesignaturethatcanpotentiallyimprovetheprognosisandpredictionofimmunizationresponsesinpapillaryrenalcellcarcinoma
AT denggao identificationofatumorinfiltrationcd8tcellgenesignaturethatcanpotentiallyimprovetheprognosisandpredictionofimmunizationresponsesinpapillaryrenalcellcarcinoma
AT weiliuzhi identificationofatumorinfiltrationcd8tcellgenesignaturethatcanpotentiallyimprovetheprognosisandpredictionofimmunizationresponsesinpapillaryrenalcellcarcinoma
AT weiqiuju identificationofatumorinfiltrationcd8tcellgenesignaturethatcanpotentiallyimprovetheprognosisandpredictionofimmunizationresponsesinpapillaryrenalcellcarcinoma
AT wangzechen identificationofatumorinfiltrationcd8tcellgenesignaturethatcanpotentiallyimprovetheprognosisandpredictionofimmunizationresponsesinpapillaryrenalcellcarcinoma
AT hesiyuan identificationofatumorinfiltrationcd8tcellgenesignaturethatcanpotentiallyimprovetheprognosisandpredictionofimmunizationresponsesinpapillaryrenalcellcarcinoma
AT shenjiajia identificationofatumorinfiltrationcd8tcellgenesignaturethatcanpotentiallyimprovetheprognosisandpredictionofimmunizationresponsesinpapillaryrenalcellcarcinoma
AT soorannasuren identificationofatumorinfiltrationcd8tcellgenesignaturethatcanpotentiallyimprovetheprognosisandpredictionofimmunizationresponsesinpapillaryrenalcellcarcinoma
AT menglingzhang identificationofatumorinfiltrationcd8tcellgenesignaturethatcanpotentiallyimprovetheprognosisandpredictionofimmunizationresponsesinpapillaryrenalcellcarcinoma
AT songjian identificationofatumorinfiltrationcd8tcellgenesignaturethatcanpotentiallyimprovetheprognosisandpredictionofimmunizationresponsesinpapillaryrenalcellcarcinoma