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miRNA, lncRNA and circRNA: Targeted Molecules Full of Therapeutic Prospects in the Development of Diabetic Retinopathy
Diabetic retinopathy (DR) is a common diabetic complication and the main cause of blindness worldwide, which seriously affects the quality of life of patients. Studies have shown that noncoding RNA (ncRNA) has distinct differentiated expression in DR and plays an important role in the occurrence and...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8631471/ https://www.ncbi.nlm.nih.gov/pubmed/34858342 http://dx.doi.org/10.3389/fendo.2021.771552 |
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author | Chang, Xingyu Zhu, Guomao Cai, Zongyan Wang, Yaqi Lian, Rongna Tang, Xulei Ma, Chengxu Fu, Songbo |
author_facet | Chang, Xingyu Zhu, Guomao Cai, Zongyan Wang, Yaqi Lian, Rongna Tang, Xulei Ma, Chengxu Fu, Songbo |
author_sort | Chang, Xingyu |
collection | PubMed |
description | Diabetic retinopathy (DR) is a common diabetic complication and the main cause of blindness worldwide, which seriously affects the quality of life of patients. Studies have shown that noncoding RNA (ncRNA) has distinct differentiated expression in DR and plays an important role in the occurrence and development of DR. ncRNAs represented by microRNAs (miRNAs), lncRNAs (lncRNAs), and circRNAs (circRNAs) have been shown to be widely involved in the regulation of gene expression and affect multiple biological processes of retinopathy. This article will review three RNAs related to the occurrence and development of DR on the basis of previous studies (especially their effects on retinal microangiopathy, retinal pigment epithelial cells, and retinal nerve cells) and discuss their underlying mechanisms and connections. Overall, this review will help us better understand the role of ncRNAs in the occurrence and development of DR and provide ideas for exploring potential therapeutic directions and targets. |
format | Online Article Text |
id | pubmed-8631471 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-86314712021-12-01 miRNA, lncRNA and circRNA: Targeted Molecules Full of Therapeutic Prospects in the Development of Diabetic Retinopathy Chang, Xingyu Zhu, Guomao Cai, Zongyan Wang, Yaqi Lian, Rongna Tang, Xulei Ma, Chengxu Fu, Songbo Front Endocrinol (Lausanne) Endocrinology Diabetic retinopathy (DR) is a common diabetic complication and the main cause of blindness worldwide, which seriously affects the quality of life of patients. Studies have shown that noncoding RNA (ncRNA) has distinct differentiated expression in DR and plays an important role in the occurrence and development of DR. ncRNAs represented by microRNAs (miRNAs), lncRNAs (lncRNAs), and circRNAs (circRNAs) have been shown to be widely involved in the regulation of gene expression and affect multiple biological processes of retinopathy. This article will review three RNAs related to the occurrence and development of DR on the basis of previous studies (especially their effects on retinal microangiopathy, retinal pigment epithelial cells, and retinal nerve cells) and discuss their underlying mechanisms and connections. Overall, this review will help us better understand the role of ncRNAs in the occurrence and development of DR and provide ideas for exploring potential therapeutic directions and targets. Frontiers Media S.A. 2021-11-10 /pmc/articles/PMC8631471/ /pubmed/34858342 http://dx.doi.org/10.3389/fendo.2021.771552 Text en Copyright © 2021 Chang, Zhu, Cai, Wang, Lian, Tang, Ma and Fu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Chang, Xingyu Zhu, Guomao Cai, Zongyan Wang, Yaqi Lian, Rongna Tang, Xulei Ma, Chengxu Fu, Songbo miRNA, lncRNA and circRNA: Targeted Molecules Full of Therapeutic Prospects in the Development of Diabetic Retinopathy |
title | miRNA, lncRNA and circRNA: Targeted Molecules Full of Therapeutic Prospects in the Development of Diabetic Retinopathy |
title_full | miRNA, lncRNA and circRNA: Targeted Molecules Full of Therapeutic Prospects in the Development of Diabetic Retinopathy |
title_fullStr | miRNA, lncRNA and circRNA: Targeted Molecules Full of Therapeutic Prospects in the Development of Diabetic Retinopathy |
title_full_unstemmed | miRNA, lncRNA and circRNA: Targeted Molecules Full of Therapeutic Prospects in the Development of Diabetic Retinopathy |
title_short | miRNA, lncRNA and circRNA: Targeted Molecules Full of Therapeutic Prospects in the Development of Diabetic Retinopathy |
title_sort | mirna, lncrna and circrna: targeted molecules full of therapeutic prospects in the development of diabetic retinopathy |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8631471/ https://www.ncbi.nlm.nih.gov/pubmed/34858342 http://dx.doi.org/10.3389/fendo.2021.771552 |
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