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Pancreatic Cancer and Platelets Crosstalk: A Potential Biomarker and Target
Platelets have been recognized as key players in hemostasis, thrombosis, and cancer. Preclinical and clinical researches evidenced that tumorigenesis and metastasis can be promoted by platelets through a wide variety of crosstalk between cancer cells and platelets. Pancreatic cancer is a devastating...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8631477/ https://www.ncbi.nlm.nih.gov/pubmed/34858977 http://dx.doi.org/10.3389/fcell.2021.749689 |
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author | Mai, Shaoshan Inkielewicz-Stepniak, Iwona |
author_facet | Mai, Shaoshan Inkielewicz-Stepniak, Iwona |
author_sort | Mai, Shaoshan |
collection | PubMed |
description | Platelets have been recognized as key players in hemostasis, thrombosis, and cancer. Preclinical and clinical researches evidenced that tumorigenesis and metastasis can be promoted by platelets through a wide variety of crosstalk between cancer cells and platelets. Pancreatic cancer is a devastating disease with high morbidity and mortality worldwide. Although the relationship between pancreatic cancer and platelets in clinical diagnosis is described, the interplay between pancreatic cancer and platelets, the underlying pathological mechanism and pathways remain a matter of intensive study. This review summaries recent researches in connections between platelets and pancreatic cancer. The existing data showed different underlying mechanisms were involved in their complex crosstalk. Typically, pancreatic tumor accelerates platelet aggregation which forms thrombosis. Furthermore, extracellular vesicles released by platelets promote communication in a neoplastic microenvironment and illustrate how these interactions drive disease progression. We also discuss the advantages of novel model organoids in pancreatic cancer research. A more in-depth understanding of tumor and platelets crosstalk which is based on organoids and translational therapies may provide potential diagnostic and therapeutic strategies for pancreatic cancer progression. |
format | Online Article Text |
id | pubmed-8631477 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-86314772021-12-01 Pancreatic Cancer and Platelets Crosstalk: A Potential Biomarker and Target Mai, Shaoshan Inkielewicz-Stepniak, Iwona Front Cell Dev Biol Cell and Developmental Biology Platelets have been recognized as key players in hemostasis, thrombosis, and cancer. Preclinical and clinical researches evidenced that tumorigenesis and metastasis can be promoted by platelets through a wide variety of crosstalk between cancer cells and platelets. Pancreatic cancer is a devastating disease with high morbidity and mortality worldwide. Although the relationship between pancreatic cancer and platelets in clinical diagnosis is described, the interplay between pancreatic cancer and platelets, the underlying pathological mechanism and pathways remain a matter of intensive study. This review summaries recent researches in connections between platelets and pancreatic cancer. The existing data showed different underlying mechanisms were involved in their complex crosstalk. Typically, pancreatic tumor accelerates platelet aggregation which forms thrombosis. Furthermore, extracellular vesicles released by platelets promote communication in a neoplastic microenvironment and illustrate how these interactions drive disease progression. We also discuss the advantages of novel model organoids in pancreatic cancer research. A more in-depth understanding of tumor and platelets crosstalk which is based on organoids and translational therapies may provide potential diagnostic and therapeutic strategies for pancreatic cancer progression. Frontiers Media S.A. 2021-11-10 /pmc/articles/PMC8631477/ /pubmed/34858977 http://dx.doi.org/10.3389/fcell.2021.749689 Text en Copyright © 2021 Mai and Inkielewicz-Stepniak. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Mai, Shaoshan Inkielewicz-Stepniak, Iwona Pancreatic Cancer and Platelets Crosstalk: A Potential Biomarker and Target |
title | Pancreatic Cancer and Platelets Crosstalk: A Potential Biomarker and Target |
title_full | Pancreatic Cancer and Platelets Crosstalk: A Potential Biomarker and Target |
title_fullStr | Pancreatic Cancer and Platelets Crosstalk: A Potential Biomarker and Target |
title_full_unstemmed | Pancreatic Cancer and Platelets Crosstalk: A Potential Biomarker and Target |
title_short | Pancreatic Cancer and Platelets Crosstalk: A Potential Biomarker and Target |
title_sort | pancreatic cancer and platelets crosstalk: a potential biomarker and target |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8631477/ https://www.ncbi.nlm.nih.gov/pubmed/34858977 http://dx.doi.org/10.3389/fcell.2021.749689 |
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