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Pancreatic Cancer and Platelets Crosstalk: A Potential Biomarker and Target

Platelets have been recognized as key players in hemostasis, thrombosis, and cancer. Preclinical and clinical researches evidenced that tumorigenesis and metastasis can be promoted by platelets through a wide variety of crosstalk between cancer cells and platelets. Pancreatic cancer is a devastating...

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Autores principales: Mai, Shaoshan, Inkielewicz-Stepniak, Iwona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8631477/
https://www.ncbi.nlm.nih.gov/pubmed/34858977
http://dx.doi.org/10.3389/fcell.2021.749689
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author Mai, Shaoshan
Inkielewicz-Stepniak, Iwona
author_facet Mai, Shaoshan
Inkielewicz-Stepniak, Iwona
author_sort Mai, Shaoshan
collection PubMed
description Platelets have been recognized as key players in hemostasis, thrombosis, and cancer. Preclinical and clinical researches evidenced that tumorigenesis and metastasis can be promoted by platelets through a wide variety of crosstalk between cancer cells and platelets. Pancreatic cancer is a devastating disease with high morbidity and mortality worldwide. Although the relationship between pancreatic cancer and platelets in clinical diagnosis is described, the interplay between pancreatic cancer and platelets, the underlying pathological mechanism and pathways remain a matter of intensive study. This review summaries recent researches in connections between platelets and pancreatic cancer. The existing data showed different underlying mechanisms were involved in their complex crosstalk. Typically, pancreatic tumor accelerates platelet aggregation which forms thrombosis. Furthermore, extracellular vesicles released by platelets promote communication in a neoplastic microenvironment and illustrate how these interactions drive disease progression. We also discuss the advantages of novel model organoids in pancreatic cancer research. A more in-depth understanding of tumor and platelets crosstalk which is based on organoids and translational therapies may provide potential diagnostic and therapeutic strategies for pancreatic cancer progression.
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spelling pubmed-86314772021-12-01 Pancreatic Cancer and Platelets Crosstalk: A Potential Biomarker and Target Mai, Shaoshan Inkielewicz-Stepniak, Iwona Front Cell Dev Biol Cell and Developmental Biology Platelets have been recognized as key players in hemostasis, thrombosis, and cancer. Preclinical and clinical researches evidenced that tumorigenesis and metastasis can be promoted by platelets through a wide variety of crosstalk between cancer cells and platelets. Pancreatic cancer is a devastating disease with high morbidity and mortality worldwide. Although the relationship between pancreatic cancer and platelets in clinical diagnosis is described, the interplay between pancreatic cancer and platelets, the underlying pathological mechanism and pathways remain a matter of intensive study. This review summaries recent researches in connections between platelets and pancreatic cancer. The existing data showed different underlying mechanisms were involved in their complex crosstalk. Typically, pancreatic tumor accelerates platelet aggregation which forms thrombosis. Furthermore, extracellular vesicles released by platelets promote communication in a neoplastic microenvironment and illustrate how these interactions drive disease progression. We also discuss the advantages of novel model organoids in pancreatic cancer research. A more in-depth understanding of tumor and platelets crosstalk which is based on organoids and translational therapies may provide potential diagnostic and therapeutic strategies for pancreatic cancer progression. Frontiers Media S.A. 2021-11-10 /pmc/articles/PMC8631477/ /pubmed/34858977 http://dx.doi.org/10.3389/fcell.2021.749689 Text en Copyright © 2021 Mai and Inkielewicz-Stepniak. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Mai, Shaoshan
Inkielewicz-Stepniak, Iwona
Pancreatic Cancer and Platelets Crosstalk: A Potential Biomarker and Target
title Pancreatic Cancer and Platelets Crosstalk: A Potential Biomarker and Target
title_full Pancreatic Cancer and Platelets Crosstalk: A Potential Biomarker and Target
title_fullStr Pancreatic Cancer and Platelets Crosstalk: A Potential Biomarker and Target
title_full_unstemmed Pancreatic Cancer and Platelets Crosstalk: A Potential Biomarker and Target
title_short Pancreatic Cancer and Platelets Crosstalk: A Potential Biomarker and Target
title_sort pancreatic cancer and platelets crosstalk: a potential biomarker and target
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8631477/
https://www.ncbi.nlm.nih.gov/pubmed/34858977
http://dx.doi.org/10.3389/fcell.2021.749689
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