Magnetic Resonance Imaging in Subacute Sclerosing Panencephalitis: Two Case Reports and Review of Literature

Subacute sclerosing panencephalitis (SSPE) is a slowly progressive neurodegenerative disease caused by the measles virus. This study investigated the magnetic resonance imaging (MRI) findings in SSPE by retrospective review of two cases diagnosed by typical periodic electroencephalographic (EEG) fea...

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Autores principales: Barthwal, Saumitra, Kaur, Narinder, Kaur, Ravinder, Zaidi, Ruma, Randev, Shivani
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2021
Materias:
Pediatrics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8631486/
https://www.ncbi.nlm.nih.gov/pubmed/34873504
http://dx.doi.org/10.7759/cureus.19161
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author Barthwal, Saumitra
Kaur, Narinder
Kaur, Ravinder
Zaidi, Ruma
Randev, Shivani
author_facet Barthwal, Saumitra
Kaur, Narinder
Kaur, Ravinder
Zaidi, Ruma
Randev, Shivani
author_sort Barthwal, Saumitra
collection PubMed
description Subacute sclerosing panencephalitis (SSPE) is a slowly progressive neurodegenerative disease caused by the measles virus. This study investigated the magnetic resonance imaging (MRI) findings in SSPE by retrospective review of two cases diagnosed by typical periodic electroencephalographic (EEG) features, clinical symptoms and elevated measles antibody titre in cerebrospinal fluid (CSF). MRI revealed lesions of high signal intensity on T2-weighted images involving the periventricular or subcortical white matter in both the patients. Both these patients were given sodium valproate for seizures. However, the disease proved fatal in both these cases eventually.
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spelling pubmed-86314862021-12-05 Magnetic Resonance Imaging in Subacute Sclerosing Panencephalitis: Two Case Reports and Review of Literature Barthwal, Saumitra Kaur, Narinder Kaur, Ravinder Zaidi, Ruma Randev, Shivani Cureus Pediatrics Subacute sclerosing panencephalitis (SSPE) is a slowly progressive neurodegenerative disease caused by the measles virus. This study investigated the magnetic resonance imaging (MRI) findings in SSPE by retrospective review of two cases diagnosed by typical periodic electroencephalographic (EEG) features, clinical symptoms and elevated measles antibody titre in cerebrospinal fluid (CSF). MRI revealed lesions of high signal intensity on T2-weighted images involving the periventricular or subcortical white matter in both the patients. Both these patients were given sodium valproate for seizures. However, the disease proved fatal in both these cases eventually. Cureus 2021-10-31 /pmc/articles/PMC8631486/ /pubmed/34873504 http://dx.doi.org/10.7759/cureus.19161 Text en Copyright © 2021, Barthwal et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Pediatrics
Barthwal, Saumitra
Kaur, Narinder
Kaur, Ravinder
Zaidi, Ruma
Randev, Shivani
Magnetic Resonance Imaging in Subacute Sclerosing Panencephalitis: Two Case Reports and Review of Literature
title Magnetic Resonance Imaging in Subacute Sclerosing Panencephalitis: Two Case Reports and Review of Literature
title_full Magnetic Resonance Imaging in Subacute Sclerosing Panencephalitis: Two Case Reports and Review of Literature
title_fullStr Magnetic Resonance Imaging in Subacute Sclerosing Panencephalitis: Two Case Reports and Review of Literature
title_full_unstemmed Magnetic Resonance Imaging in Subacute Sclerosing Panencephalitis: Two Case Reports and Review of Literature
title_short Magnetic Resonance Imaging in Subacute Sclerosing Panencephalitis: Two Case Reports and Review of Literature
title_sort magnetic resonance imaging in subacute sclerosing panencephalitis: two case reports and review of literature
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8631486/
https://www.ncbi.nlm.nih.gov/pubmed/34873504
http://dx.doi.org/10.7759/cureus.19161
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