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Alternative poly-adenylation modulates α1-antitrypsin expression in chronic obstructive pulmonary disease

α1-anti-trypsin (A1AT), encoded by SERPINA1, is a neutrophil elastase inhibitor that controls the inflammatory response in the lung. Severe A1AT deficiency increases risk for Chronic Obstructive Pulmonary Disease (COPD), however, the role of A1AT in COPD in non-deficient individuals is not well know...

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Detalles Bibliográficos
Autores principales:	Lackey, Lela, Coria, Aaztli, Ghosh, Auyon J., Grayeski, Phil, Hatfield, Abigail, Shankar, Vijay, Platig, John, Xu, Zhonghui, Ramos, Silvia B. V., Silverman, Edwin K., Ortega, Victor E., Cho, Michael H., Hersh, Craig P., Hobbs, Brian D., Castaldi, Peter, Laederach, Alain
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8631626/ https://www.ncbi.nlm.nih.gov/pubmed/34784346 http://dx.doi.org/10.1371/journal.pgen.1009912

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