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Reteplase Fc-fusions produced in N. benthamiana are able to dissolve blood clots ex vivo

Thrombolytic and fibrinolytic therapies are effective treatments to dissolve blood clots in stroke therapy. Thrombolytic drugs activate plasminogen to its cleaved form plasmin, a proteolytic enzyme that breaks the crosslinks between fibrin molecules. The FDA-approved human tissue plasminogen activat...

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Detalles Bibliográficos
Autores principales:	Izadi, Shiva, Jalali Javaran, Mokhtar, Rashidi Monfared, Sajad, Castilho, Alexandra
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8631678/ https://www.ncbi.nlm.nih.gov/pubmed/34847186 http://dx.doi.org/10.1371/journal.pone.0260796

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