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High incidence of Trypanosoma cruzi infections in dogs directly detected through longitudinal tracking at 10 multi-dog kennels, Texas, USA
Canine Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, is increasingly recognized as a health concern for dogs in the USA, and infected dogs may signal geographic regions of risk for human disease. Dogs living in multi-dog kennel environments (kennels with more than one dog) wher...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8631682/ https://www.ncbi.nlm.nih.gov/pubmed/34758049 http://dx.doi.org/10.1371/journal.pntd.0009935 |
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author | Busselman, Rachel E. Meyers, Alyssa C. Zecca, Italo B. Auckland, Lisa D. Castro, Andres H. Dowd, Rebecca E. Curtis-Robles, Rachel Hodo, Carolyn L. Saunders, Ashley B. Hamer, Sarah A. |
author_facet | Busselman, Rachel E. Meyers, Alyssa C. Zecca, Italo B. Auckland, Lisa D. Castro, Andres H. Dowd, Rebecca E. Curtis-Robles, Rachel Hodo, Carolyn L. Saunders, Ashley B. Hamer, Sarah A. |
author_sort | Busselman, Rachel E. |
collection | PubMed |
description | Canine Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, is increasingly recognized as a health concern for dogs in the USA, and infected dogs may signal geographic regions of risk for human disease. Dogs living in multi-dog kennel environments (kennels with more than one dog) where triatomine vectors are endemic may be at high risk for infection. We monitored a cohort of 64 T. cruzi-infected and uninfected dogs across 10 kennels in Texas, USA, to characterize changes in infection status over one year. We used robust diagnostic criteria in which reactivity on multiple independent platforms was required to be considered positive. Among the 30 dogs enrolled as serologically- and/or PCR-positive, all but one dog showed sustained positive T. cruzi diagnostic results over time. Among the 34 dogs enrolled as serologically- and PCR-negative, 10 new T. cruzi infections were recorded over a 12-month period. The resulting incidence rate for dogs initially enrolled as T. cruzi-negative was 30.7 T. cruzi infections per 100 dogs per year. This study highlights the risk of T. cruzi infection to dogs in kennel environments. To protect both dog and human health, there is an urgent need to develop more integrated vector control methods as well as prophylactic and curative antiparasitic treatment options for T. cruzi infection in dogs. |
format | Online Article Text |
id | pubmed-8631682 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-86316822021-12-01 High incidence of Trypanosoma cruzi infections in dogs directly detected through longitudinal tracking at 10 multi-dog kennels, Texas, USA Busselman, Rachel E. Meyers, Alyssa C. Zecca, Italo B. Auckland, Lisa D. Castro, Andres H. Dowd, Rebecca E. Curtis-Robles, Rachel Hodo, Carolyn L. Saunders, Ashley B. Hamer, Sarah A. PLoS Negl Trop Dis Research Article Canine Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, is increasingly recognized as a health concern for dogs in the USA, and infected dogs may signal geographic regions of risk for human disease. Dogs living in multi-dog kennel environments (kennels with more than one dog) where triatomine vectors are endemic may be at high risk for infection. We monitored a cohort of 64 T. cruzi-infected and uninfected dogs across 10 kennels in Texas, USA, to characterize changes in infection status over one year. We used robust diagnostic criteria in which reactivity on multiple independent platforms was required to be considered positive. Among the 30 dogs enrolled as serologically- and/or PCR-positive, all but one dog showed sustained positive T. cruzi diagnostic results over time. Among the 34 dogs enrolled as serologically- and PCR-negative, 10 new T. cruzi infections were recorded over a 12-month period. The resulting incidence rate for dogs initially enrolled as T. cruzi-negative was 30.7 T. cruzi infections per 100 dogs per year. This study highlights the risk of T. cruzi infection to dogs in kennel environments. To protect both dog and human health, there is an urgent need to develop more integrated vector control methods as well as prophylactic and curative antiparasitic treatment options for T. cruzi infection in dogs. Public Library of Science 2021-11-10 /pmc/articles/PMC8631682/ /pubmed/34758049 http://dx.doi.org/10.1371/journal.pntd.0009935 Text en © 2021 Busselman et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Busselman, Rachel E. Meyers, Alyssa C. Zecca, Italo B. Auckland, Lisa D. Castro, Andres H. Dowd, Rebecca E. Curtis-Robles, Rachel Hodo, Carolyn L. Saunders, Ashley B. Hamer, Sarah A. High incidence of Trypanosoma cruzi infections in dogs directly detected through longitudinal tracking at 10 multi-dog kennels, Texas, USA |
title | High incidence of Trypanosoma cruzi infections in dogs directly detected through longitudinal tracking at 10 multi-dog kennels, Texas, USA |
title_full | High incidence of Trypanosoma cruzi infections in dogs directly detected through longitudinal tracking at 10 multi-dog kennels, Texas, USA |
title_fullStr | High incidence of Trypanosoma cruzi infections in dogs directly detected through longitudinal tracking at 10 multi-dog kennels, Texas, USA |
title_full_unstemmed | High incidence of Trypanosoma cruzi infections in dogs directly detected through longitudinal tracking at 10 multi-dog kennels, Texas, USA |
title_short | High incidence of Trypanosoma cruzi infections in dogs directly detected through longitudinal tracking at 10 multi-dog kennels, Texas, USA |
title_sort | high incidence of trypanosoma cruzi infections in dogs directly detected through longitudinal tracking at 10 multi-dog kennels, texas, usa |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8631682/ https://www.ncbi.nlm.nih.gov/pubmed/34758049 http://dx.doi.org/10.1371/journal.pntd.0009935 |
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