Structure-Based Design of Selective Fat Mass and Obesity Associated Protein (FTO) Inhibitors

[Image: see text] FTO catalyzes the Fe(II) and 2-oxoglutarate (2OG)-dependent modification of nucleic acids, including the demethylation of N(6)-methyladenosine (m(6)A) in mRNA. FTO is a proposed target for anti-cancer therapy. Using information from crystal structures of FTO in complex with 2OG and...

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Detalles Bibliográficos
Autores principales: Shishodia, Shifali, Demetriades, Marina, Zhang, Dong, Tam, Nok Yin, Maheswaran, Pratheesh, Clunie-O’Connor, Caitlin, Tumber, Anthony, Leung, Ivanhoe K. H., Ng, Yi Min, Leissing, Thomas M., El-Sagheer, Afaf H., Salah, Eidarus, Brown, Tom, Aik, Wei Shen, McDonough, Michael A., Schofield, Christopher J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8631710/
https://www.ncbi.nlm.nih.gov/pubmed/34762429
http://dx.doi.org/10.1021/acs.jmedchem.1c01204

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