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CSF-Derived CD4(+) T-Cell Diversity Is Reduced in Patients With Alzheimer Clinical Syndrome

BACKGROUND AND OBJECTIVES: Patients with Alzheimer dementia display evidence of amyloid-related neurodegeneration. Our focus was to determine whether such patients also display evidence of a disease-targeting adaptive immune response mediated by CD4(+) T cells. To test this hypothesis, we evaluated...

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Detalles Bibliográficos
Autores principales:	Joshi, Chaitanya, Sivaprakasam, Karthigayini, Christley, Scott, Ireland, Sara, Rivas, Jacqueline, Zhang, Wei, Sader, Danielle, Logan, Rebecca, Lambracht-Washington, Doris, Rosenberg, Roger, Cullum, Munro, Hitt, Brian, Li, Quan-Zhen, Barber, Robert, Greenberg, Benjamin, Cowell, Lindsay, Zhang, Rong, Stowe, Ann, Huebinger, Ryan, Kelley, Brendan, Monson, Nancy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott Williams & Wilkins 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8631792/ https://www.ncbi.nlm.nih.gov/pubmed/34848502 http://dx.doi.org/10.1212/NXI.0000000000001106

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