TCR meta-clonotypes for biomarker discovery with tcrdist3 enabled identification of public, HLA-restricted clusters of SARS-CoV-2 TCRs

T-cell receptors (TCRs) encode clinically valuable information that reflects prior antigen exposure and potential future response. However, despite advances in deep repertoire sequencing, enormous TCR diversity complicates the use of TCR clonotypes as clinical biomarkers. We propose a new framework...

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Detalles Bibliográficos
Autores principales: Mayer-Blackwell, Koshlan, Schattgen, Stefan, Cohen-Lavi, Liel, Crawford, Jeremy C, Souquette, Aisha, Gaevert, Jessica A, Hertz, Tomer, Thomas, Paul G, Bradley, Philip, Fiore-Gartland, Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Computational and Systems Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8631793/
https://www.ncbi.nlm.nih.gov/pubmed/34845983
http://dx.doi.org/10.7554/eLife.68605

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8631793/
https://www.ncbi.nlm.nih.gov/pubmed/34845983
http://dx.doi.org/10.7554/eLife.68605

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