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Daily electrical activity in the master circadian clock of a diurnal mammal
Circadian rhythms in mammals are orchestrated by a central clock within the suprachiasmatic nuclei (SCN). Our understanding of the electrophysiological basis of SCN activity comes overwhelmingly from a small number of nocturnal rodent species, and the extent to which these are retained in day-active...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8631794/ https://www.ncbi.nlm.nih.gov/pubmed/34845984 http://dx.doi.org/10.7554/eLife.68179 |
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author | Bano-Otalora, Beatriz Moye, Matthew J Brown, Timothy Lucas, Robert J Diekman, Casey O Belle, Mino DC |
author_facet | Bano-Otalora, Beatriz Moye, Matthew J Brown, Timothy Lucas, Robert J Diekman, Casey O Belle, Mino DC |
author_sort | Bano-Otalora, Beatriz |
collection | PubMed |
description | Circadian rhythms in mammals are orchestrated by a central clock within the suprachiasmatic nuclei (SCN). Our understanding of the electrophysiological basis of SCN activity comes overwhelmingly from a small number of nocturnal rodent species, and the extent to which these are retained in day-active animals remains unclear. Here, we recorded the spontaneous and evoked electrical activity of single SCN neurons in the diurnal rodent Rhabdomys pumilio, and developed cutting-edge data assimilation and mathematical modeling approaches to uncover the underlying ionic mechanisms. As in nocturnal rodents, R. pumilio SCN neurons were more excited during daytime hours. By contrast, the evoked activity of R. pumilio neurons included a prominent suppressive response that is not present in the SCN of nocturnal rodents. Our modeling revealed and subsequent experiments confirmed transient subthreshold A-type potassium channels as the primary determinant of this response, and suggest a key role for this ionic mechanism in optimizing SCN function to accommodate R. pumilio’s diurnal niche. |
format | Online Article Text |
id | pubmed-8631794 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-86317942021-12-01 Daily electrical activity in the master circadian clock of a diurnal mammal Bano-Otalora, Beatriz Moye, Matthew J Brown, Timothy Lucas, Robert J Diekman, Casey O Belle, Mino DC eLife Computational and Systems Biology Circadian rhythms in mammals are orchestrated by a central clock within the suprachiasmatic nuclei (SCN). Our understanding of the electrophysiological basis of SCN activity comes overwhelmingly from a small number of nocturnal rodent species, and the extent to which these are retained in day-active animals remains unclear. Here, we recorded the spontaneous and evoked electrical activity of single SCN neurons in the diurnal rodent Rhabdomys pumilio, and developed cutting-edge data assimilation and mathematical modeling approaches to uncover the underlying ionic mechanisms. As in nocturnal rodents, R. pumilio SCN neurons were more excited during daytime hours. By contrast, the evoked activity of R. pumilio neurons included a prominent suppressive response that is not present in the SCN of nocturnal rodents. Our modeling revealed and subsequent experiments confirmed transient subthreshold A-type potassium channels as the primary determinant of this response, and suggest a key role for this ionic mechanism in optimizing SCN function to accommodate R. pumilio’s diurnal niche. eLife Sciences Publications, Ltd 2021-11-30 /pmc/articles/PMC8631794/ /pubmed/34845984 http://dx.doi.org/10.7554/eLife.68179 Text en © 2021, Bano-Otalora et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Computational and Systems Biology Bano-Otalora, Beatriz Moye, Matthew J Brown, Timothy Lucas, Robert J Diekman, Casey O Belle, Mino DC Daily electrical activity in the master circadian clock of a diurnal mammal |
title | Daily electrical activity in the master circadian clock of a diurnal mammal |
title_full | Daily electrical activity in the master circadian clock of a diurnal mammal |
title_fullStr | Daily electrical activity in the master circadian clock of a diurnal mammal |
title_full_unstemmed | Daily electrical activity in the master circadian clock of a diurnal mammal |
title_short | Daily electrical activity in the master circadian clock of a diurnal mammal |
title_sort | daily electrical activity in the master circadian clock of a diurnal mammal |
topic | Computational and Systems Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8631794/ https://www.ncbi.nlm.nih.gov/pubmed/34845984 http://dx.doi.org/10.7554/eLife.68179 |
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