Metformin Suppresses Monocyte Immunometabolic Activation by SARS-CoV-2 Spike Protein Subunit 1

A hallmark of COVID-19 is a hyperinflammatory state associated with severity. Monocytes undergo metabolic reprogramming and produce inflammatory cytokines when stimulated with SARS-CoV-2. We hypothesized that binding by the viral spike protein mediates this effect, and that drugs which regulate immu...

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Detalles Bibliográficos
Autores principales: Cory, Theodore J., Emmons, Russell S., Yarbro, Johnathan R., Davis, Kierstin L., Pence, Brandt D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8631967/
https://www.ncbi.nlm.nih.gov/pubmed/34858397
http://dx.doi.org/10.3389/fimmu.2021.733921

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8631967/
https://www.ncbi.nlm.nih.gov/pubmed/34858397
http://dx.doi.org/10.3389/fimmu.2021.733921

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