A conserved motif in human BTG1 and BTG2 proteins mediates interaction with the poly(A) binding protein PABPC1 to stimulate mRNA deadenylation

Antiproliferative BTG/Tob proteins interact directly with the CAF1 deadenylase subunit of the CCR4-NOT complex. This binding requires the presence of two conserved motifs, boxA and boxB, characteristic of the BTG/Tob APRO domain. Consistently, these proteins were shown to stimulate mRNA deadenylatio...

Descripción completa

Detalles Bibliográficos
Autores principales: Amine, Hamza, Ripin, Nina, Sharma, Sahil, Stoecklin, Georg, Allain, Frédéric H, Séraphin, Bertrand, Mauxion, Fabienne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8632095/
https://www.ncbi.nlm.nih.gov/pubmed/34060423
http://dx.doi.org/10.1080/15476286.2021.1925476

Ejemplares similares

Ejemplares similares