Postmortem Stability of SARS-CoV-2 in Mouse Lung Tissue

The infectivity of severe acute respiratory syndrome coronavirus 2 in deceased persons and organisms remains unclear. We studied transgenic K18 hACE2 mice to determine the kinetics of virus infectivity after host death. Five days after death, virus infectivity in the lung declined by >96% and RNA...

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Detalles Bibliográficos
Autores principales: Valkenburg, Sophie A., Cheng, Samuel M.S., Hachim, Asmaa, Peiris, Malik, Nicholls, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2021
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8632159/
https://www.ncbi.nlm.nih.gov/pubmed/34559046
http://dx.doi.org/10.3201/eid2712.211621
Descripción
Sumario:The infectivity of severe acute respiratory syndrome coronavirus 2 in deceased persons and organisms remains unclear. We studied transgenic K18 hACE2 mice to determine the kinetics of virus infectivity after host death. Five days after death, virus infectivity in the lung declined by >96% and RNA copies declined by 48.2%.

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