Postmortem Stability of SARS-CoV-2 in Mouse Lung Tissue

The infectivity of severe acute respiratory syndrome coronavirus 2 in deceased persons and organisms remains unclear. We studied transgenic K18 hACE2 mice to determine the kinetics of virus infectivity after host death. Five days after death, virus infectivity in the lung declined by >96% and RNA...

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Autores principales: Valkenburg, Sophie A., Cheng, Samuel M.S., Hachim, Asmaa, Peiris, Malik, Nicholls, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2021
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8632159/
https://www.ncbi.nlm.nih.gov/pubmed/34559046
http://dx.doi.org/10.3201/eid2712.211621
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author Valkenburg, Sophie A.
Cheng, Samuel M.S.
Hachim, Asmaa
Peiris, Malik
Nicholls, John
author_facet Valkenburg, Sophie A.
Cheng, Samuel M.S.
Hachim, Asmaa
Peiris, Malik
Nicholls, John
author_sort Valkenburg, Sophie A.
collection PubMed
description The infectivity of severe acute respiratory syndrome coronavirus 2 in deceased persons and organisms remains unclear. We studied transgenic K18 hACE2 mice to determine the kinetics of virus infectivity after host death. Five days after death, virus infectivity in the lung declined by >96% and RNA copies declined by 48.2%.
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spelling pubmed-86321592021-12-01 Postmortem Stability of SARS-CoV-2 in Mouse Lung Tissue Valkenburg, Sophie A. Cheng, Samuel M.S. Hachim, Asmaa Peiris, Malik Nicholls, John Emerg Infect Dis Research Letter The infectivity of severe acute respiratory syndrome coronavirus 2 in deceased persons and organisms remains unclear. We studied transgenic K18 hACE2 mice to determine the kinetics of virus infectivity after host death. Five days after death, virus infectivity in the lung declined by >96% and RNA copies declined by 48.2%. Centers for Disease Control and Prevention 2021-12 /pmc/articles/PMC8632159/ /pubmed/34559046 http://dx.doi.org/10.3201/eid2712.211621 Text en https://creativecommons.org/licenses/by/4.0/Emerging Infectious Diseases is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research Letter
Valkenburg, Sophie A.
Cheng, Samuel M.S.
Hachim, Asmaa
Peiris, Malik
Nicholls, John
Postmortem Stability of SARS-CoV-2 in Mouse Lung Tissue
title Postmortem Stability of SARS-CoV-2 in Mouse Lung Tissue
title_full Postmortem Stability of SARS-CoV-2 in Mouse Lung Tissue
title_fullStr Postmortem Stability of SARS-CoV-2 in Mouse Lung Tissue
title_full_unstemmed Postmortem Stability of SARS-CoV-2 in Mouse Lung Tissue
title_short Postmortem Stability of SARS-CoV-2 in Mouse Lung Tissue
title_sort postmortem stability of sars-cov-2 in mouse lung tissue
topic Research Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8632159/
https://www.ncbi.nlm.nih.gov/pubmed/34559046
http://dx.doi.org/10.3201/eid2712.211621
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