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SARS-CoV-2 Seroprevalence in a Rural and Urban Household Cohort during First and Second Waves of Infections, South Africa, July 2020–March 2021
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections may be underestimated because of limited access to testing. We measured SARS-CoV-2 seroprevalence in South Africa every 2 months during July 2020–March 2021 in randomly selected household cohorts in 2 communities. We compared se...
Autores principales: | , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Centers for Disease Control and Prevention
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8632160/ https://www.ncbi.nlm.nih.gov/pubmed/34477548 http://dx.doi.org/10.3201/eid2712.211465 |
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author | Kleynhans, Jackie Tempia, Stefano Wolter, Nicole von Gottberg, Anne Bhiman, Jinal N. Buys, Amelia Moyes, Jocelyn McMorrow, Meredith L. Kahn, Kathleen Gómez-Olivé, F. Xavier Tollman, Stephen Martinson, Neil A. Wafawanaka, Floidy Lebina, Limakatso du Toit, Jacques Jassat, Waasila Neti, Mzimasi Brauer, Marieke Cohen, Cheryl |
author_facet | Kleynhans, Jackie Tempia, Stefano Wolter, Nicole von Gottberg, Anne Bhiman, Jinal N. Buys, Amelia Moyes, Jocelyn McMorrow, Meredith L. Kahn, Kathleen Gómez-Olivé, F. Xavier Tollman, Stephen Martinson, Neil A. Wafawanaka, Floidy Lebina, Limakatso du Toit, Jacques Jassat, Waasila Neti, Mzimasi Brauer, Marieke Cohen, Cheryl |
author_sort | Kleynhans, Jackie |
collection | PubMed |
description | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections may be underestimated because of limited access to testing. We measured SARS-CoV-2 seroprevalence in South Africa every 2 months during July 2020–March 2021 in randomly selected household cohorts in 2 communities. We compared seroprevalence to reported laboratory-confirmed infections, hospitalizations, and deaths to calculate infection–case, infection–hospitalization, and infection–fatality ratios in 2 waves of infection. Post–second wave seroprevalence ranged from 18% in the rural community children <5 years of age, to 59% in urban community adults 35–59 years of age. The second wave saw a shift in age distribution of case-patients in the urban community (from persons 35–59 years of age to persons at the extremes of age), higher attack rates in the rural community, and a higher infection–fatality ratio in the urban community. Approximately 95% of SARS-CoV-2 infections were not reported to national surveillance. |
format | Online Article Text |
id | pubmed-8632160 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Centers for Disease Control and Prevention |
record_format | MEDLINE/PubMed |
spelling | pubmed-86321602021-12-01 SARS-CoV-2 Seroprevalence in a Rural and Urban Household Cohort during First and Second Waves of Infections, South Africa, July 2020–March 2021 Kleynhans, Jackie Tempia, Stefano Wolter, Nicole von Gottberg, Anne Bhiman, Jinal N. Buys, Amelia Moyes, Jocelyn McMorrow, Meredith L. Kahn, Kathleen Gómez-Olivé, F. Xavier Tollman, Stephen Martinson, Neil A. Wafawanaka, Floidy Lebina, Limakatso du Toit, Jacques Jassat, Waasila Neti, Mzimasi Brauer, Marieke Cohen, Cheryl Emerg Infect Dis Research Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections may be underestimated because of limited access to testing. We measured SARS-CoV-2 seroprevalence in South Africa every 2 months during July 2020–March 2021 in randomly selected household cohorts in 2 communities. We compared seroprevalence to reported laboratory-confirmed infections, hospitalizations, and deaths to calculate infection–case, infection–hospitalization, and infection–fatality ratios in 2 waves of infection. Post–second wave seroprevalence ranged from 18% in the rural community children <5 years of age, to 59% in urban community adults 35–59 years of age. The second wave saw a shift in age distribution of case-patients in the urban community (from persons 35–59 years of age to persons at the extremes of age), higher attack rates in the rural community, and a higher infection–fatality ratio in the urban community. Approximately 95% of SARS-CoV-2 infections were not reported to national surveillance. Centers for Disease Control and Prevention 2021-12 /pmc/articles/PMC8632160/ /pubmed/34477548 http://dx.doi.org/10.3201/eid2712.211465 Text en https://creativecommons.org/licenses/by/4.0/Emerging Infectious Diseases is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited. |
spellingShingle | Research Kleynhans, Jackie Tempia, Stefano Wolter, Nicole von Gottberg, Anne Bhiman, Jinal N. Buys, Amelia Moyes, Jocelyn McMorrow, Meredith L. Kahn, Kathleen Gómez-Olivé, F. Xavier Tollman, Stephen Martinson, Neil A. Wafawanaka, Floidy Lebina, Limakatso du Toit, Jacques Jassat, Waasila Neti, Mzimasi Brauer, Marieke Cohen, Cheryl SARS-CoV-2 Seroprevalence in a Rural and Urban Household Cohort during First and Second Waves of Infections, South Africa, July 2020–March 2021 |
title | SARS-CoV-2 Seroprevalence in a Rural and Urban Household Cohort during First and Second Waves of Infections, South Africa, July 2020–March 2021 |
title_full | SARS-CoV-2 Seroprevalence in a Rural and Urban Household Cohort during First and Second Waves of Infections, South Africa, July 2020–March 2021 |
title_fullStr | SARS-CoV-2 Seroprevalence in a Rural and Urban Household Cohort during First and Second Waves of Infections, South Africa, July 2020–March 2021 |
title_full_unstemmed | SARS-CoV-2 Seroprevalence in a Rural and Urban Household Cohort during First and Second Waves of Infections, South Africa, July 2020–March 2021 |
title_short | SARS-CoV-2 Seroprevalence in a Rural and Urban Household Cohort during First and Second Waves of Infections, South Africa, July 2020–March 2021 |
title_sort | sars-cov-2 seroprevalence in a rural and urban household cohort during first and second waves of infections, south africa, july 2020–march 2021 |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8632160/ https://www.ncbi.nlm.nih.gov/pubmed/34477548 http://dx.doi.org/10.3201/eid2712.211465 |
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