Experimental Oronasal Transmission of Chronic Wasting Disease Agent from White-Tailed Deer to Suffolk Sheep

Chronic wasting disease (CWD) is a fatal prion disease of cervids. We examined host range of CWD by oronasally inoculating Suffolk sheep with brain homogenate from a CWD-positive white-tailed deer. Sixty months after inoculation, 1/7 sheep had immunoreactivity against the misfolded form of prion pro...

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Detalles Bibliográficos
Autores principales: Cassmann, Eric D., Moore, S. Jo, Greenlee, Justin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2021
Materias:
Dispatch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8632196/
https://www.ncbi.nlm.nih.gov/pubmed/34808075
http://dx.doi.org/10.3201/eid2712.204978
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author Cassmann, Eric D.
Moore, S. Jo
Greenlee, Justin J.
author_facet Cassmann, Eric D.
Moore, S. Jo
Greenlee, Justin J.
author_sort Cassmann, Eric D.
collection PubMed
description Chronic wasting disease (CWD) is a fatal prion disease of cervids. We examined host range of CWD by oronasally inoculating Suffolk sheep with brain homogenate from a CWD-positive white-tailed deer. Sixty months after inoculation, 1/7 sheep had immunoreactivity against the misfolded form of prion protein in lymphoid tissue. Results were confirmed by mouse bioassay.
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spelling pubmed-86321962021-12-01 Experimental Oronasal Transmission of Chronic Wasting Disease Agent from White-Tailed Deer to Suffolk Sheep Cassmann, Eric D. Moore, S. Jo Greenlee, Justin J. Emerg Infect Dis Dispatch Chronic wasting disease (CWD) is a fatal prion disease of cervids. We examined host range of CWD by oronasally inoculating Suffolk sheep with brain homogenate from a CWD-positive white-tailed deer. Sixty months after inoculation, 1/7 sheep had immunoreactivity against the misfolded form of prion protein in lymphoid tissue. Results were confirmed by mouse bioassay. Centers for Disease Control and Prevention 2021-12 /pmc/articles/PMC8632196/ /pubmed/34808075 http://dx.doi.org/10.3201/eid2712.204978 Text en https://creativecommons.org/licenses/by/4.0/Emerging Infectious Diseases is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Dispatch
Cassmann, Eric D.
Moore, S. Jo
Greenlee, Justin J.
Experimental Oronasal Transmission of Chronic Wasting Disease Agent from White-Tailed Deer to Suffolk Sheep
title Experimental Oronasal Transmission of Chronic Wasting Disease Agent from White-Tailed Deer to Suffolk Sheep
title_full Experimental Oronasal Transmission of Chronic Wasting Disease Agent from White-Tailed Deer to Suffolk Sheep
title_fullStr Experimental Oronasal Transmission of Chronic Wasting Disease Agent from White-Tailed Deer to Suffolk Sheep
title_full_unstemmed Experimental Oronasal Transmission of Chronic Wasting Disease Agent from White-Tailed Deer to Suffolk Sheep
title_short Experimental Oronasal Transmission of Chronic Wasting Disease Agent from White-Tailed Deer to Suffolk Sheep
title_sort experimental oronasal transmission of chronic wasting disease agent from white-tailed deer to suffolk sheep
topic Dispatch
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8632196/
https://www.ncbi.nlm.nih.gov/pubmed/34808075
http://dx.doi.org/10.3201/eid2712.204978
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