Cargando…

Interaction Between Commensal Bacteria, Immune Response and the Intestinal Barrier in Inflammatory Bowel Disease

In inflammatory bowel disease (IBD), intestinal mucosa cell and intestinal epithelial cell are severely damaged, and then their susceptibility to bacteria increases, so many commensal bacteria become pathogenic. The pathogenic commensal bacteria can stimulate a series of compensatory immune response...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Yongyan, Cui, Wenwen, Li, Xiao, Yang, Huan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8632219/
https://www.ncbi.nlm.nih.gov/pubmed/34858414
http://dx.doi.org/10.3389/fimmu.2021.761981
_version_ 1784607715204530176
author Chen, Yongyan
Cui, Wenwen
Li, Xiao
Yang, Huan
author_facet Chen, Yongyan
Cui, Wenwen
Li, Xiao
Yang, Huan
author_sort Chen, Yongyan
collection PubMed
description In inflammatory bowel disease (IBD), intestinal mucosa cell and intestinal epithelial cell are severely damaged, and then their susceptibility to bacteria increases, so many commensal bacteria become pathogenic. The pathogenic commensal bacteria can stimulate a series of compensatory immune responses in the intestine. However, the immune response prevents the intestinal tract from restoring homeostasis, which in turn produces an indispensable inflammatory response. On the contrary, in IBD, the fierce inflammatory response contributes to the development of IBD. However, the effect of commensal bacteria on inflammation in IBD has not been clearly studied. Therefore, we further summarize the changes brought about by the changes of commensal bacteria to the inflammation of the intestines and their mutual influence. This article reviews the protective mechanism of commensal bacteria in healthy people and the mechanism of commensal bacteria and immune response to the destruction of the intestinal barrier when IBD occurs. The treatment and prevention of IBD are also briefly summarized.
format Online
Article
Text
id pubmed-8632219
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-86322192021-12-01 Interaction Between Commensal Bacteria, Immune Response and the Intestinal Barrier in Inflammatory Bowel Disease Chen, Yongyan Cui, Wenwen Li, Xiao Yang, Huan Front Immunol Immunology In inflammatory bowel disease (IBD), intestinal mucosa cell and intestinal epithelial cell are severely damaged, and then their susceptibility to bacteria increases, so many commensal bacteria become pathogenic. The pathogenic commensal bacteria can stimulate a series of compensatory immune responses in the intestine. However, the immune response prevents the intestinal tract from restoring homeostasis, which in turn produces an indispensable inflammatory response. On the contrary, in IBD, the fierce inflammatory response contributes to the development of IBD. However, the effect of commensal bacteria on inflammation in IBD has not been clearly studied. Therefore, we further summarize the changes brought about by the changes of commensal bacteria to the inflammation of the intestines and their mutual influence. This article reviews the protective mechanism of commensal bacteria in healthy people and the mechanism of commensal bacteria and immune response to the destruction of the intestinal barrier when IBD occurs. The treatment and prevention of IBD are also briefly summarized. Frontiers Media S.A. 2021-11-11 /pmc/articles/PMC8632219/ /pubmed/34858414 http://dx.doi.org/10.3389/fimmu.2021.761981 Text en Copyright © 2021 Chen, Cui, Li and Yang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Chen, Yongyan
Cui, Wenwen
Li, Xiao
Yang, Huan
Interaction Between Commensal Bacteria, Immune Response and the Intestinal Barrier in Inflammatory Bowel Disease
title Interaction Between Commensal Bacteria, Immune Response and the Intestinal Barrier in Inflammatory Bowel Disease
title_full Interaction Between Commensal Bacteria, Immune Response and the Intestinal Barrier in Inflammatory Bowel Disease
title_fullStr Interaction Between Commensal Bacteria, Immune Response and the Intestinal Barrier in Inflammatory Bowel Disease
title_full_unstemmed Interaction Between Commensal Bacteria, Immune Response and the Intestinal Barrier in Inflammatory Bowel Disease
title_short Interaction Between Commensal Bacteria, Immune Response and the Intestinal Barrier in Inflammatory Bowel Disease
title_sort interaction between commensal bacteria, immune response and the intestinal barrier in inflammatory bowel disease
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8632219/
https://www.ncbi.nlm.nih.gov/pubmed/34858414
http://dx.doi.org/10.3389/fimmu.2021.761981
work_keys_str_mv AT chenyongyan interactionbetweencommensalbacteriaimmuneresponseandtheintestinalbarrierininflammatoryboweldisease
AT cuiwenwen interactionbetweencommensalbacteriaimmuneresponseandtheintestinalbarrierininflammatoryboweldisease
AT lixiao interactionbetweencommensalbacteriaimmuneresponseandtheintestinalbarrierininflammatoryboweldisease
AT yanghuan interactionbetweencommensalbacteriaimmuneresponseandtheintestinalbarrierininflammatoryboweldisease