Cargando…

Screening of a Small Molecule Compound Library Identifies Toosendanin as an Inhibitor Against Bunyavirus and SARS-CoV-2

Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging tick-borne virus causing serious infectious disease with a high case-fatality of up to 50% in severe cases. Currently, no effective drug has been approved for the treatment of SFTSV infection. Here, we performed a high-throughp...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Shufen, Ye, Meidi, Chen, Yuanqiao, Zhang, Yulan, Li, Jiachen, Liu, Wei, Li, Hao, Peng, Ke
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8632254/ https://www.ncbi.nlm.nih.gov/pubmed/34858173 http://dx.doi.org/10.3389/fphar.2021.735223

Ejemplares similares

Natural Compound Library Screening Identifies Oroxin A for the Treatment of Myocardial Ischemia/Reperfusion Injury
por: Cheng, Xingdong, et al.
Publicado: (2022)

Screening of a Focused Ubiquitin-Proteasome Pathway Inhibitor Library Identifies Small Molecules as Novel Modulators of Botulinum Neurotoxin Type A Toxicity
por: Sen, Edanur, et al.
Publicado: (2021)

Toosendanin From Melia Fructus Suppresses Influenza A Virus Infection by Altering Nuclear Localization of Viral Polymerase PA Protein
por: Jin, Young-Hee, et al.
Publicado: (2019)

In Vivo Dopamine Neuron Imaging-Based Small Molecule Screen Identifies Novel Neuroprotective Compounds and Targets
por: Kim, Gha-hyun J., et al.
Publicado: (2022)

Expanding diversity of bunyaviruses identified in mosquitoes
por: Orba, Yasuko, et al.
Publicado: (2023)

Toosendanin, a late-stage autophagy inhibitor, sensitizes triple-negative breast cancer to irinotecan chemotherapy
por: Zhang, Shuang, et al.
Publicado: (2022)

Application of temperature-responsive HIS-tag fluorophores to differential scanning fluorimetry screening of small molecule libraries
por: Ronzetti, Michael H., et al.
Publicado: (2022)

Toosendanin demonstrates promising antitumor efficacy in osteosarcoma by targeting STAT3
por: Zhang, T, et al.
Publicado: (2017)

Bunyavirus-Vector Interactions
por: Horne, Kate McElroy, et al.
Publicado: (2014)

Natural Compound Library Screening Identifies New Molecules for the Treatment of Cardiac Fibrosis and Diastolic Dysfunction
por: Schimmel, Katharina, et al.
Publicado: (2020)

Toosendanin inhibits adipogenesis by activating Wnt/β-catenin signaling
por: Chen, Tian-xing, et al.
Publicado: (2018)

Mechanisms involved in the anti-tumor effects of Toosendanin in glioma cells
por: Zhang, Chaochao, et al.
Publicado: (2021)

Correction: Toosendanin demonstrates promising antitumor efficacy in osteosarcoma by targeting STAT3
por: Zhang, T., et al.
Publicado: (2019)

Entry of Bunyaviruses into Mammalian Cells
por: Lozach, Pierre-Yves, et al.
Publicado: (2010)

An Overview of the Infectious Cycle of Bunyaviruses
por: Boshra, Hani
Publicado: (2022)

Compound library screening identified Akt/PKB kinase pathway inhibitors as potential key molecules for the development of new chemotherapeutics against schistosomiasis
por: Morel, Marion, et al.
Publicado: (2014)

Discovery of METTL3 Small Molecule Inhibitors by Virtual Screening of Natural Products
por: Du, Yue, et al.
Publicado: (2022)

A highly pathogenic new bunyavirus emerged in China
por: Li, Dexin
Publicado: (2013)

Screening of compound libraries for inhibitors of Toxoplasma growth and invasion
por: Han, Yongmei, et al.
Publicado: (2020)

Use of a Fission Yeast Platform to Identify and Characterize Small Molecule PDE Inhibitors
por: Hoffman, Charles S.
Publicado: (2022)

Compound screen identifies the small molecule Q34 as an inhibitor of SARS-CoV-2 infection
por: Cui, Qi, et al.
Publicado: (2021)

Toosendanin Induces Hepatocyte Damage by Inhibiting Autophagic Flux via TFEB-Mediated Lysosomal Dysfunction
por: Luo, Li, et al.
Publicado: (2022)

theLiTE™: A Screening Platform to Identify Compounds that Reinforce Tight Junctions
por: Gomes, Teresa Lopes, et al.
Publicado: (2022)

Bunyaviruses and the Type I Interferon System
por: Elliott, Richard M., et al.
Publicado: (2009)

Early Bunyavirus-Host Cell Interactions
por: Albornoz, Amelina, et al.
Publicado: (2016)

The mechanism of genome replication and transcription in bunyaviruses
por: Malet, Hélène, et al.
Publicado: (2023)

Screening of an FDA-approved compound library identifies apigenin for the treatment of myocardial injury
por: Li, Haixia, et al.
Publicado: (2023)

Making Bunyaviruses Talk: Interrogation Tactics to Identify Host Factors Required for Infection
por: Riblett, Amber M., et al.
Publicado: (2016)

Screening for Small Molecule Inhibitors of Statin-Induced APP C-terminal Toxic Fragment Production
por: Poksay, Karen S., et al.
Publicado: (2017)

Drugs for Autoimmune Inflammatory Diseases: From Small Molecule Compounds to Anti-TNF Biologics
por: Li, Ping, et al.
Publicado: (2017)

Phenotypic Screen Identifies a Small Molecule Modulating ERK2 and Promoting Stem Cell Proliferation
por: Yin, Chang, et al.
Publicado: (2017)

Antioxidant Small Molecule Compound Chrysin Promotes the Self-Renewal of Hematopoietic Stem Cells
por: Li, Yinghui, et al.
Publicado: (2020)

Identification of cap-dependent endonuclease inhibitors with broad-spectrum activity against bunyaviruses
por: Toba, Shinsuke, et al.
Publicado: (2022)

Toosendanin, a novel potent vacuolar-type H(+)-translocating ATPase inhibitor, sensitizes cancer cells to chemotherapy by blocking protective autophagy
por: Dong, Yu, et al.
Publicado: (2022)

An Enhanced Hybrid Screening Approach to Identify Potent Inhibitors for the SARS-CoV-2 Main Protease From the NCI Compound Library
por: Li, Shuhua G., et al.
Publicado: (2022)

The Apoptotic Effects of Toosendanin Are Partially Mediated by Activation of Deoxycytidine Kinase in HL-60 Cells
por: Ju, Jianming, et al.
Publicado: (2012)

Toosendanin induces the apoptosis of human Ewing's sarcoma cells via the mitochondrial apoptotic pathway
por: Gao, Tian, et al.
Publicado: (2019)

Novel Nonnucleoside Inhibitors of Zika Virus Polymerase Identified through the Screening of an Open Library of Antikinetoplastid Compounds
por: Sáez-Álvarez, Yanira, et al.
Publicado: (2021)

Person-to-Person Transmission of Severe Fever With Thrombocytopenia Syndrome Bunyavirus Through Blood Contact
por: Gai, Zhongtao, et al.
Publicado: (2012)

Small-molecule compounds inhibiting S-phase kinase-associated protein 2: A review
por: Jing, Jia, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_vkl5fhcae0oqiaqb5a1fsc8raf