Exposure to 10 Hz Pulsed Magnetic Fields Do Not Induce Cellular Senescence in Human Fetal Lung Fibroblasts

Rapid population aging has led to a global burden of late-life diseases. As the largest risk factor for a multitude of age-related diseases, aging is not only the result of genotype but also closely related to external factors. With the rapid expansion in the usage of electromagnetic fields (EMFs),...

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Autores principales: Sun, Chuan, Huang, Zheng, Qin, Houbing, Zhang, Jing, Wang, Sanying, Xu, Xiaogang, Ying, Shibo, Mao, Genxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Public Health
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8632261/
https://www.ncbi.nlm.nih.gov/pubmed/34858933
http://dx.doi.org/10.3389/fpubh.2021.761069
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author Sun, Chuan
Huang, Zheng
Qin, Houbing
Zhang, Jing
Wang, Sanying
Xu, Xiaogang
Ying, Shibo
Mao, Genxiang
author_facet Sun, Chuan
Huang, Zheng
Qin, Houbing
Zhang, Jing
Wang, Sanying
Xu, Xiaogang
Ying, Shibo
Mao, Genxiang
author_sort Sun, Chuan
collection PubMed
description Rapid population aging has led to a global burden of late-life diseases. As the largest risk factor for a multitude of age-related diseases, aging is not only the result of genotype but also closely related to external factors. With the rapid expansion in the usage of electromagnetic fields (EMFs), the effect of EMFs on aging has also attracted attention. Cells are the basic unit of organs and body tissues, and cellular senescence plays an important role in the aging process. The effect of EMFs on cellular senescence has been investigated in a few studies, but the information is limited, and the results are inconsistent; thus, further investigation is required. In this study, we investigated the effect of 10 Hz pulsed magnetic fields (MFs) on cellular senescence in a 2BS cell line, isolated from human fetal lung fibroblasts, and found that intermittent (1 d on/1 d off) exposure to 10 Hz pulsed MFs at 1.0 mT for 2 weeks induced DNA damage, but no other significant phenotype of cellular senescence in 2BS cells.
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spelling pubmed-86322612021-12-01 Exposure to 10 Hz Pulsed Magnetic Fields Do Not Induce Cellular Senescence in Human Fetal Lung Fibroblasts Sun, Chuan Huang, Zheng Qin, Houbing Zhang, Jing Wang, Sanying Xu, Xiaogang Ying, Shibo Mao, Genxiang Front Public Health Public Health Rapid population aging has led to a global burden of late-life diseases. As the largest risk factor for a multitude of age-related diseases, aging is not only the result of genotype but also closely related to external factors. With the rapid expansion in the usage of electromagnetic fields (EMFs), the effect of EMFs on aging has also attracted attention. Cells are the basic unit of organs and body tissues, and cellular senescence plays an important role in the aging process. The effect of EMFs on cellular senescence has been investigated in a few studies, but the information is limited, and the results are inconsistent; thus, further investigation is required. In this study, we investigated the effect of 10 Hz pulsed magnetic fields (MFs) on cellular senescence in a 2BS cell line, isolated from human fetal lung fibroblasts, and found that intermittent (1 d on/1 d off) exposure to 10 Hz pulsed MFs at 1.0 mT for 2 weeks induced DNA damage, but no other significant phenotype of cellular senescence in 2BS cells. Frontiers Media S.A. 2021-11-11 /pmc/articles/PMC8632261/ /pubmed/34858933 http://dx.doi.org/10.3389/fpubh.2021.761069 Text en Copyright © 2021 Sun, Huang, Qin, Zhang, Wang, Xu, Ying and Mao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Public Health
Sun, Chuan
Huang, Zheng
Qin, Houbing
Zhang, Jing
Wang, Sanying
Xu, Xiaogang
Ying, Shibo
Mao, Genxiang
Exposure to 10 Hz Pulsed Magnetic Fields Do Not Induce Cellular Senescence in Human Fetal Lung Fibroblasts
title Exposure to 10 Hz Pulsed Magnetic Fields Do Not Induce Cellular Senescence in Human Fetal Lung Fibroblasts
title_full Exposure to 10 Hz Pulsed Magnetic Fields Do Not Induce Cellular Senescence in Human Fetal Lung Fibroblasts
title_fullStr Exposure to 10 Hz Pulsed Magnetic Fields Do Not Induce Cellular Senescence in Human Fetal Lung Fibroblasts
title_full_unstemmed Exposure to 10 Hz Pulsed Magnetic Fields Do Not Induce Cellular Senescence in Human Fetal Lung Fibroblasts
title_short Exposure to 10 Hz Pulsed Magnetic Fields Do Not Induce Cellular Senescence in Human Fetal Lung Fibroblasts
title_sort exposure to 10 hz pulsed magnetic fields do not induce cellular senescence in human fetal lung fibroblasts
topic Public Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8632261/
https://www.ncbi.nlm.nih.gov/pubmed/34858933
http://dx.doi.org/10.3389/fpubh.2021.761069
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