A scientific journey from discovery to validation of efficacy in cancer patients: HAMLET and alpha1-oleate

The protein-lipid complex alpha1-oleate, derived from HAMLET (Human Alpha-lactalbumin Made LEthal to Tumor cells), is identified as a molecular entity with significant therapeutic potential. Structural characterization of the complex and results of a successful placebo-controlled clinical trial are...

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Detalles Bibliográficos
Autores principales: Ho, James C.S., Ambite, Ines, Mok, K. H., Babjuk, Marek, Svanborg, Catharina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Author’s Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8632289/
https://www.ncbi.nlm.nih.gov/pubmed/34859140
http://dx.doi.org/10.1080/23723556.2021.1974278
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author Ho, James C.S.
Ambite, Ines
Mok, K. H.
Babjuk, Marek
Svanborg, Catharina
author_facet Ho, James C.S.
Ambite, Ines
Mok, K. H.
Babjuk, Marek
Svanborg, Catharina
author_sort Ho, James C.S.
collection PubMed
description The protein-lipid complex alpha1-oleate, derived from HAMLET (Human Alpha-lactalbumin Made LEthal to Tumor cells), is identified as a molecular entity with significant therapeutic potential. Structural characterization of the complex and results of a successful placebo-controlled clinical trial are presented.
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spelling pubmed-86322892021-12-01 A scientific journey from discovery to validation of efficacy in cancer patients: HAMLET and alpha1-oleate Ho, James C.S. Ambite, Ines Mok, K. H. Babjuk, Marek Svanborg, Catharina Mol Cell Oncol Author’s Views The protein-lipid complex alpha1-oleate, derived from HAMLET (Human Alpha-lactalbumin Made LEthal to Tumor cells), is identified as a molecular entity with significant therapeutic potential. Structural characterization of the complex and results of a successful placebo-controlled clinical trial are presented. Taylor & Francis 2021-09-30 /pmc/articles/PMC8632289/ /pubmed/34859140 http://dx.doi.org/10.1080/23723556.2021.1974278 Text en © 2021 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author’s Views
Ho, James C.S.
Ambite, Ines
Mok, K. H.
Babjuk, Marek
Svanborg, Catharina
A scientific journey from discovery to validation of efficacy in cancer patients: HAMLET and alpha1-oleate
title A scientific journey from discovery to validation of efficacy in cancer patients: HAMLET and alpha1-oleate
title_full A scientific journey from discovery to validation of efficacy in cancer patients: HAMLET and alpha1-oleate
title_fullStr A scientific journey from discovery to validation of efficacy in cancer patients: HAMLET and alpha1-oleate
title_full_unstemmed A scientific journey from discovery to validation of efficacy in cancer patients: HAMLET and alpha1-oleate
title_short A scientific journey from discovery to validation of efficacy in cancer patients: HAMLET and alpha1-oleate
title_sort scientific journey from discovery to validation of efficacy in cancer patients: hamlet and alpha1-oleate
topic Author’s Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8632289/
https://www.ncbi.nlm.nih.gov/pubmed/34859140
http://dx.doi.org/10.1080/23723556.2021.1974278
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