Hydrogen-deuterium exchange mass spectrometry reveals three unique binding responses of mAbs directed to the catalytic domain of hCAIX

Human carbonic anhydrase (hCAIX), an extracellular enzyme that catalyzes the reversible hydration of CO(2), is often overexpressed in solid tumors. This enzyme is instrumental in maintaining the survival of cancer cells in a hypoxic and acidic tumor microenvironment. Absent in most normal tissues, h...

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Detalles Bibliográficos
Autores principales: Sheff, Joey G., Kelly, John F., Robotham, Anna, Sulea, Traian, Malenfant, Félix, L’Abbé, Denis, Duchesne, Mélanie, Pelletier, Alex, Lefebvre, Jean, Acel, Andrea, Parat, Marie, Gosselin, Mylene, Wu, Cunle, Fortin, Yves, Baardsnes, Jason, Van Faassen, Henk, Awrey, Shannon, Chafe, Shawn C., McDonald, Paul C., Dedhar, Shoukat, Lenferink, Anne E.G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8632303/
https://www.ncbi.nlm.nih.gov/pubmed/34812124
http://dx.doi.org/10.1080/19420862.2021.1997072

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