Cargando…

CD122-targeted interleukin-2 and αPD-L1 treat bladder cancer and melanoma via distinct mechanisms, including CD122-driven natural killer cell maturation

Bladder cancer (BC) and melanoma are amenable to immune checkpoint blockade (ICB) therapy, yet most patients with advanced/metastatic disease do not respond. CD122-targeted interleukin (IL)-2 can improve ICB efficacy, but mechanisms are unclear. We tested αPD-L1 and CD122-directed immunotherapy with...

Descripción completa

Detalles Bibliográficos
Autores principales:	Reyes, Ryan M, Zhang, Chenghao, Deng, Yilun, Ji, Niannian, Mukherjee, Neelam, Padron, Alvaro S, Clark, Curtis A, Svatek, Robert S, Curiel, Tyler J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8632314/ https://www.ncbi.nlm.nih.gov/pubmed/34858732 http://dx.doi.org/10.1080/2162402X.2021.2006529

Ejemplares similares

CD122-directed interleukin-2 treatment mechanisms in bladder cancer differ from αPD-L1 and include tissue-selective γδ T cell activation
por: Reyes, Ryan Michael, et al.
Publicado: (2021)

$^{120}$Cd and $^{122}$Cd
por: Scheidemann, Ø, et al.
Publicado: (1973)

Intratumoral CD56(bright) natural killer cells are associated with improved survival in bladder cancer
por: Mukherjee, Neelam, et al.
Publicado: (2018)

TREM2 promotes natural killer cell development in CD3(−)CD122(+)NK1.1(+) pNK cells
por: Lee, Hwa-Youn, et al.
Publicado: (2021)

Essential Roles of CD8(+)CD122(+) Regulatory T Cells in the Maintenance of T Cell Homeostasis
por: Rifa'i, Muhaimin, et al.
Publicado: (2004)

Circulating CD8(+)CD122(+) T cells as a prognostic indicator of pancreatic cancer
por: Teramatsu, Katsuhito, et al.
Publicado: (2022)

CD8+CD122+PD-1+ Tregs Synergize With Costimulatory Blockade of CD40/CD154, but Not B7/CD28, to Prolong Murine Allograft Survival
por: Liu, Huazhen, et al.
Publicado: (2019)

4579 Distinct clinical and immunological responses to αPD-1, kαPD-L1 and αPD-L2 immunotherapy in B16 melanoma in aged versus young hosts includes T-cell stem cell effects and PD-L2 expression differences
por: Garcia, Myrna G, et al.
Publicado: (2020)

Targeting of CD122 enhances antitumor immunity by altering the tumor immune environment
por: Villarreal, Daniel O., et al.
Publicado: (2017)

CD8(+)CD122(+) T-Cells: A Newly Emerging Regulator with Central Memory Cell Phenotypes
por: Liu, Junfeng, et al.
Publicado: (2015)

Resveratrol exerts antitumor effects by downregulating CD8(+)CD122(+) Tregs in murine hepatocellular carcinoma
por: Zhang, Qunfang, et al.
Publicado: (2020)

Runs 117, 122 and 122': Tests of septum magnet for experiment R 201
por: Bonaudi, Franco
Publicado: (1971)

Spectroscopy of neutron-rich $^{122,124}$Cd isotopes via d,p reactions
por: Benito, Jaime
Publicado: (2022)

Expansion of circulating stem-like CD8(+) T cells by adding CD122-directed IL-2 complexes to radiation and anti-PD1 therapies in mice
por: Onyshchenko, Kateryna, et al.
Publicado: (2023)

Chinese medicine Ginseng and Astragalus granules ameliorate autoimmune diabetes by upregulating both CD4+FoxP3+ and CD8+CD122+PD1+ regulatory T cells
por: Wang, Yeshu, et al.
Publicado: (2017)

122nd LHCC Meeting
Publicado: (2015)

Progress Report of the S122 experiment
por: CERN. Geneva. Electronic Experiments Committee
Publicado: (1973)

122nd SPSC Meeting
Publicado: (2016)

122 Peptide Inhibitors of HIV
por: Vahlne, Anders
Publicado: (2014)

Population Pharmacokinetics of CC-122
por: Cheng, Yiming, et al.
Publicado: (2021)

Health Tract, No. 122: Housewifery
Publicado: (1863)

Health Tract, No. 122: Housewifery
Publicado: (1865)

Antitumor Immunity Produced by the Liver Kupffer Cells, NK Cells, NKT Cells, and CD8(+) CD122(+) T Cells
por: Seki, Shuhji, et al.
Publicado: (2011)

Herbal Components of a Novel Formula PSORI-CM02 Interdependently Suppress Allograft Rejection and Induce CD8+CD122+PD-1+ Regulatory T Cells
por: Lu, Chuanjian, et al.
Publicado: (2018)

Energy levels in 114,116,118,120,122Cd populated in the decay of Ag isotopes
por: Bäcklin, A, et al.
Publicado: (1970)

Active glycolytic metabolism in CD133(+) hepatocellular cancer stem cells: regulation by MIR-122
por: Song, Kyoungsub, et al.
Publicado: (2015)

Anti-CD122 antibody restores specific CD8(+) T cell response in nonalcoholic steatohepatitis and prevents hepatocellular carcinoma growth
por: Lacotte, Stéphanie, et al.
Publicado: (2023)

Synergistic antitumor activity of the CD122-biased immunostimulatory cytokine NKTR-214 when combined with anti-PD-1 in murine tumor models
por: Murali, Addepalli, et al.
Publicado: (2015)

Suppression of allograft rejection by CD8+CD122+PD-1+ Tregs is dictated by their Fas ligand-initiated killing of effector T cells versus Fas-mediated own apoptosis
por: Liu, Huazhen, et al.
Publicado: (2017)

KLRF1, a novel marker of CD56(bright) NK cells, predicts improved survival for patients with locally advanced bladder cancer
por: Mukherjee, Neelam, et al.
Publicado: (2022)

A Review of 122 Consecutive Hysterectomies
por: Macafee, C. H. G.
Publicado: (1934)

Colloquium No. 122 of the International Astronomical Union
por: Cassatella, A, et al.
Publicado: (1990)

Hepatitis C virus genetics affects miR-122 requirements and response to miR-122 inhibitors
por: Israelow, Benjamin, et al.
Publicado: (2014)

MicroRNA-122 Regulation of HCV Infections: Insights from Studies of miR-122-Independent Replication
por: Panigrahi, Mamata, et al.
Publicado: (2022)

CD122-targetted IL-2 signals cause acute and selective apoptosis of B cells in Peyer’s Patches
por: Singh, Ayushi, et al.
Publicado: (2020)

Chronic shift‐lag promotes NK cell ageing and impairs immunosurveillance in mice by decreasing the expression of CD122
por: Zeng, Xiaokang, et al.
Publicado: (2020)

421 Specific cephalosporin antibiotics deplete tumor PD-L1 to inhibit DNA damage sensing and sensitize to Chk1 inhibitors in vivo
por: Murray, Clare, et al.
Publicado: (2022)

The LAA project (CERN-EP-87-122)
por: Zichichi, Antonino
Publicado: (1987)

Revised evaluation of proposal SPSC-P-122
por: CERN. Geneva. SPS Experiments Committee
Publicado: (1979)

122nd IAU Symposium on Circumstellar Matter
por: Collective
Publicado: (1987)

Cannot write session to /tmp/vufind_sessions/sess_9i9okki5ndv2thunfudotkr133