Simplifying cancer: binary pan-cancer superclasses stratified by opposite YAP/TEAD effects

The inherent complexity of cancer complicates treatment. Identifying higher-order principles that govern cancer biology can circumvent this problem and pinpoint broadly applicable treatment options. We recently found that opposite expression and pro- versus anti-cancer activity of a single transcrip...

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Detalles Bibliográficos
Autores principales: Pearson, Joel D., Bremner, Rod
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Author’s Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8632326/
https://www.ncbi.nlm.nih.gov/pubmed/34859143
http://dx.doi.org/10.1080/23723556.2021.1981111
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author Pearson, Joel D.
Bremner, Rod
author_facet Pearson, Joel D.
Bremner, Rod
author_sort Pearson, Joel D.
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description The inherent complexity of cancer complicates treatment. Identifying higher-order principles that govern cancer biology can circumvent this problem and pinpoint broadly applicable treatment options. We recently found that opposite expression and pro- versus anti-cancer activity of a single transcriptional complex functionally stratifies cancer into binary superclasses.
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spelling pubmed-86323262021-12-01 Simplifying cancer: binary pan-cancer superclasses stratified by opposite YAP/TEAD effects Pearson, Joel D. Bremner, Rod Mol Cell Oncol Author’s Views The inherent complexity of cancer complicates treatment. Identifying higher-order principles that govern cancer biology can circumvent this problem and pinpoint broadly applicable treatment options. We recently found that opposite expression and pro- versus anti-cancer activity of a single transcriptional complex functionally stratifies cancer into binary superclasses. Taylor & Francis 2021-09-24 /pmc/articles/PMC8632326/ /pubmed/34859143 http://dx.doi.org/10.1080/23723556.2021.1981111 Text en © 2021 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author’s Views
Pearson, Joel D.
Bremner, Rod
Simplifying cancer: binary pan-cancer superclasses stratified by opposite YAP/TEAD effects
title Simplifying cancer: binary pan-cancer superclasses stratified by opposite YAP/TEAD effects
title_full Simplifying cancer: binary pan-cancer superclasses stratified by opposite YAP/TEAD effects
title_fullStr Simplifying cancer: binary pan-cancer superclasses stratified by opposite YAP/TEAD effects
title_full_unstemmed Simplifying cancer: binary pan-cancer superclasses stratified by opposite YAP/TEAD effects
title_short Simplifying cancer: binary pan-cancer superclasses stratified by opposite YAP/TEAD effects
title_sort simplifying cancer: binary pan-cancer superclasses stratified by opposite yap/tead effects
topic Author’s Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8632326/
https://www.ncbi.nlm.nih.gov/pubmed/34859143
http://dx.doi.org/10.1080/23723556.2021.1981111
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