Adipose stromal cells promote the transition of colorectal cancer cells toward a mesenchymal-like phenotype

Colon cancer progression is among the risks that increase with obesity. We have recently unveiled the molecular mechanism by which adipose tissue-released molecules, HGF and IL-6, make colorectal cancer (CRC) cells acquiring mesenchymal traits. Targeting of adipose-derived factors abrogate the metas...

Descripción completa

Detalles Bibliográficos
Autores principales: Di Franco, Simone, Stassi, Giorgio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8632327/
https://www.ncbi.nlm.nih.gov/pubmed/34859146
http://dx.doi.org/10.1080/23723556.2021.1986343
Descripción
Sumario:Colon cancer progression is among the risks that increase with obesity. We have recently unveiled the molecular mechanism by which adipose tissue-released molecules, HGF and IL-6, make colorectal cancer (CRC) cells acquiring mesenchymal traits. Targeting of adipose-derived factors abrogate the metastatic potential of CRC stem cells (CR-CSCs) in obese patients.

Ejemplares similares