Adipose stromal cells promote the transition of colorectal cancer cells toward a mesenchymal-like phenotype

Colon cancer progression is among the risks that increase with obesity. We have recently unveiled the molecular mechanism by which adipose tissue-released molecules, HGF and IL-6, make colorectal cancer (CRC) cells acquiring mesenchymal traits. Targeting of adipose-derived factors abrogate the metas...

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Detalles Bibliográficos
Autores principales: Di Franco, Simone, Stassi, Giorgio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8632327/
https://www.ncbi.nlm.nih.gov/pubmed/34859146
http://dx.doi.org/10.1080/23723556.2021.1986343
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author Di Franco, Simone
Stassi, Giorgio
author_facet Di Franco, Simone
Stassi, Giorgio
author_sort Di Franco, Simone
collection PubMed
description Colon cancer progression is among the risks that increase with obesity. We have recently unveiled the molecular mechanism by which adipose tissue-released molecules, HGF and IL-6, make colorectal cancer (CRC) cells acquiring mesenchymal traits. Targeting of adipose-derived factors abrogate the metastatic potential of CRC stem cells (CR-CSCs) in obese patients.
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spelling pubmed-86323272021-12-01 Adipose stromal cells promote the transition of colorectal cancer cells toward a mesenchymal-like phenotype Di Franco, Simone Stassi, Giorgio Mol Cell Oncol Commentary Colon cancer progression is among the risks that increase with obesity. We have recently unveiled the molecular mechanism by which adipose tissue-released molecules, HGF and IL-6, make colorectal cancer (CRC) cells acquiring mesenchymal traits. Targeting of adipose-derived factors abrogate the metastatic potential of CRC stem cells (CR-CSCs) in obese patients. Taylor & Francis 2021-10-18 /pmc/articles/PMC8632327/ /pubmed/34859146 http://dx.doi.org/10.1080/23723556.2021.1986343 Text en © 2021 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Commentary
Di Franco, Simone
Stassi, Giorgio
Adipose stromal cells promote the transition of colorectal cancer cells toward a mesenchymal-like phenotype
title Adipose stromal cells promote the transition of colorectal cancer cells toward a mesenchymal-like phenotype
title_full Adipose stromal cells promote the transition of colorectal cancer cells toward a mesenchymal-like phenotype
title_fullStr Adipose stromal cells promote the transition of colorectal cancer cells toward a mesenchymal-like phenotype
title_full_unstemmed Adipose stromal cells promote the transition of colorectal cancer cells toward a mesenchymal-like phenotype
title_short Adipose stromal cells promote the transition of colorectal cancer cells toward a mesenchymal-like phenotype
title_sort adipose stromal cells promote the transition of colorectal cancer cells toward a mesenchymal-like phenotype
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8632327/
https://www.ncbi.nlm.nih.gov/pubmed/34859146
http://dx.doi.org/10.1080/23723556.2021.1986343
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