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Gender Variations in the Oral Microbiomes of Elderly Patients with Initial Periodontitis
Periodontitis is a globally prevalent disease that imposes a functional and aesthetic burden on patients. The oral microbiome influences human health. The aim of this study was at assessing gender variation in the subgingival bacterial microbiome of elderly patients with initial periodontitis and to...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8632398/ https://www.ncbi.nlm.nih.gov/pubmed/34859107 http://dx.doi.org/10.1155/2021/7403042 |
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author | Zhao, Jie Zhou, Ying-Hui Zhao, Ya-Qiong Feng, Yao Yan, Fei Gao, Zheng-Rong Ye, Qin Chen, Yun Liu, Qiong Tan, Li Zhang, Shao-Hui Hu, Jing Dusenge, Marie Aimee Feng, Yun-Zhi Guo, Yue |
author_facet | Zhao, Jie Zhou, Ying-Hui Zhao, Ya-Qiong Feng, Yao Yan, Fei Gao, Zheng-Rong Ye, Qin Chen, Yun Liu, Qiong Tan, Li Zhang, Shao-Hui Hu, Jing Dusenge, Marie Aimee Feng, Yun-Zhi Guo, Yue |
author_sort | Zhao, Jie |
collection | PubMed |
description | Periodontitis is a globally prevalent disease that imposes a functional and aesthetic burden on patients. The oral microbiome influences human health. The aim of this study was at assessing gender variation in the subgingival bacterial microbiome of elderly patients with initial periodontitis and to determine the causes of this variation. Twelve males and twenty females (range 50–68 years old) with initial periodontitis provided subgingival plaque samples. 16S rRNA gene sequencing, QIIME-based data processing, and statistical analyses were carried out using several different analytical approaches to detect differences in the oral microbiome between the two groups. Males had higher Chao1 index, observed species, and phylogenetic diversity whole tree values than females. Analysis of β-diversity indicated that the samples were reasonably divided by the gender. The linear discriminant analysis effect size showed that the most representative biomarkers were the genus Haemophilus in males, whereas the dominant bacteria in females were Campylobacter. Kyoto Encyclopedia of Genes and Genomes analysis showed that predicting changes in the female oral microbiota may be related to the immune system and immune system diseases are the main factor in males. These data suggest that gender may be a differentiating factor in the microbial composition of subgingival plaques in elderly patients with initial periodontitis. These results could deepen our understanding of the role of gender in the oral microbiota present during initial periodontitis. |
format | Online Article Text |
id | pubmed-8632398 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-86323982021-12-01 Gender Variations in the Oral Microbiomes of Elderly Patients with Initial Periodontitis Zhao, Jie Zhou, Ying-Hui Zhao, Ya-Qiong Feng, Yao Yan, Fei Gao, Zheng-Rong Ye, Qin Chen, Yun Liu, Qiong Tan, Li Zhang, Shao-Hui Hu, Jing Dusenge, Marie Aimee Feng, Yun-Zhi Guo, Yue J Immunol Res Research Article Periodontitis is a globally prevalent disease that imposes a functional and aesthetic burden on patients. The oral microbiome influences human health. The aim of this study was at assessing gender variation in the subgingival bacterial microbiome of elderly patients with initial periodontitis and to determine the causes of this variation. Twelve males and twenty females (range 50–68 years old) with initial periodontitis provided subgingival plaque samples. 16S rRNA gene sequencing, QIIME-based data processing, and statistical analyses were carried out using several different analytical approaches to detect differences in the oral microbiome between the two groups. Males had higher Chao1 index, observed species, and phylogenetic diversity whole tree values than females. Analysis of β-diversity indicated that the samples were reasonably divided by the gender. The linear discriminant analysis effect size showed that the most representative biomarkers were the genus Haemophilus in males, whereas the dominant bacteria in females were Campylobacter. Kyoto Encyclopedia of Genes and Genomes analysis showed that predicting changes in the female oral microbiota may be related to the immune system and immune system diseases are the main factor in males. These data suggest that gender may be a differentiating factor in the microbial composition of subgingival plaques in elderly patients with initial periodontitis. These results could deepen our understanding of the role of gender in the oral microbiota present during initial periodontitis. Hindawi 2021-11-23 /pmc/articles/PMC8632398/ /pubmed/34859107 http://dx.doi.org/10.1155/2021/7403042 Text en Copyright © 2021 Jie Zhao et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Zhao, Jie Zhou, Ying-Hui Zhao, Ya-Qiong Feng, Yao Yan, Fei Gao, Zheng-Rong Ye, Qin Chen, Yun Liu, Qiong Tan, Li Zhang, Shao-Hui Hu, Jing Dusenge, Marie Aimee Feng, Yun-Zhi Guo, Yue Gender Variations in the Oral Microbiomes of Elderly Patients with Initial Periodontitis |
title | Gender Variations in the Oral Microbiomes of Elderly Patients with Initial Periodontitis |
title_full | Gender Variations in the Oral Microbiomes of Elderly Patients with Initial Periodontitis |
title_fullStr | Gender Variations in the Oral Microbiomes of Elderly Patients with Initial Periodontitis |
title_full_unstemmed | Gender Variations in the Oral Microbiomes of Elderly Patients with Initial Periodontitis |
title_short | Gender Variations in the Oral Microbiomes of Elderly Patients with Initial Periodontitis |
title_sort | gender variations in the oral microbiomes of elderly patients with initial periodontitis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8632398/ https://www.ncbi.nlm.nih.gov/pubmed/34859107 http://dx.doi.org/10.1155/2021/7403042 |
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