SARS-CoV-2 immunogenicity in individuals infected before and after COVID-19 vaccination: Israel, January–March 2021

Between December 2020 and March 2021, we measured anti-SARS-CoV-2 IgG titres among 725 Israeli hospital workers vaccinated against COVID-19. Infection post-dose 1 vaccination did not increase IgG titres, and individuals infected post-dose 1 had IgG levels comparable to never-infected individuals who...

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Autores principales: Abu Jabal, Kamal, Ben-Amram, Hila, Beiruti, Karine, Brimat, Ira, Abu Saada, Ashraf, Bathish, Younes, Sussan, Christian, Zarka, Salman, Edelstein, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2021
Materias:
From the Field
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8632408/
https://www.ncbi.nlm.nih.gov/pubmed/34399868
http://dx.doi.org/10.1017/S0950268821001928
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author Abu Jabal, Kamal
Ben-Amram, Hila
Beiruti, Karine
Brimat, Ira
Abu Saada, Ashraf
Bathish, Younes
Sussan, Christian
Zarka, Salman
Edelstein, Michael
author_facet Abu Jabal, Kamal
Ben-Amram, Hila
Beiruti, Karine
Brimat, Ira
Abu Saada, Ashraf
Bathish, Younes
Sussan, Christian
Zarka, Salman
Edelstein, Michael
author_sort Abu Jabal, Kamal
collection PubMed
description Between December 2020 and March 2021, we measured anti-SARS-CoV-2 IgG titres among 725 Israeli hospital workers vaccinated against COVID-19. Infection post-dose 1 vaccination did not increase IgG titres, and individuals infected post-dose 1 had IgG levels comparable to never-infected individuals who received a single dose, lower than fully vaccinated, never-infected individuals. This suggests dose 2, currently not offered to those infected post-dose 1, may be required in these individuals. Larger studies should confirm whether individuals infected post-dose 1 need the second.
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spelling pubmed-86324082021-12-02 SARS-CoV-2 immunogenicity in individuals infected before and after COVID-19 vaccination: Israel, January–March 2021 Abu Jabal, Kamal Ben-Amram, Hila Beiruti, Karine Brimat, Ira Abu Saada, Ashraf Bathish, Younes Sussan, Christian Zarka, Salman Edelstein, Michael Epidemiol Infect From the Field Between December 2020 and March 2021, we measured anti-SARS-CoV-2 IgG titres among 725 Israeli hospital workers vaccinated against COVID-19. Infection post-dose 1 vaccination did not increase IgG titres, and individuals infected post-dose 1 had IgG levels comparable to never-infected individuals who received a single dose, lower than fully vaccinated, never-infected individuals. This suggests dose 2, currently not offered to those infected post-dose 1, may be required in these individuals. Larger studies should confirm whether individuals infected post-dose 1 need the second. Cambridge University Press 2021-08-17 /pmc/articles/PMC8632408/ /pubmed/34399868 http://dx.doi.org/10.1017/S0950268821001928 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.
spellingShingle From the Field
Abu Jabal, Kamal
Ben-Amram, Hila
Beiruti, Karine
Brimat, Ira
Abu Saada, Ashraf
Bathish, Younes
Sussan, Christian
Zarka, Salman
Edelstein, Michael
SARS-CoV-2 immunogenicity in individuals infected before and after COVID-19 vaccination: Israel, January–March 2021
title SARS-CoV-2 immunogenicity in individuals infected before and after COVID-19 vaccination: Israel, January–March 2021
title_full SARS-CoV-2 immunogenicity in individuals infected before and after COVID-19 vaccination: Israel, January–March 2021
title_fullStr SARS-CoV-2 immunogenicity in individuals infected before and after COVID-19 vaccination: Israel, January–March 2021
title_full_unstemmed SARS-CoV-2 immunogenicity in individuals infected before and after COVID-19 vaccination: Israel, January–March 2021
title_short SARS-CoV-2 immunogenicity in individuals infected before and after COVID-19 vaccination: Israel, January–March 2021
title_sort sars-cov-2 immunogenicity in individuals infected before and after covid-19 vaccination: israel, january–march 2021
topic From the Field
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8632408/
https://www.ncbi.nlm.nih.gov/pubmed/34399868
http://dx.doi.org/10.1017/S0950268821001928
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