The Hippo Signaling Pathway: The Trader of Tumor Microenvironment

The Hippo pathway regulates cancer biology in many aspects and the crosstalk with other pathways complicates its role. Accumulated evidence has shown that the bidirectional interactions between tumor cells and tumor microenvironment (TME) are the premises of tumor occurrence, development, and metast...

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Detalles Bibliográficos
Autores principales: Yang, Duo, Zhang, Na, Li, Meihua, Hong, Tao, Meng, Wei, Ouyang, Taohui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8632547/
https://www.ncbi.nlm.nih.gov/pubmed/34858852
http://dx.doi.org/10.3389/fonc.2021.772134
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author Yang, Duo
Zhang, Na
Li, Meihua
Hong, Tao
Meng, Wei
Ouyang, Taohui
author_facet Yang, Duo
Zhang, Na
Li, Meihua
Hong, Tao
Meng, Wei
Ouyang, Taohui
author_sort Yang, Duo
collection PubMed
description The Hippo pathway regulates cancer biology in many aspects and the crosstalk with other pathways complicates its role. Accumulated evidence has shown that the bidirectional interactions between tumor cells and tumor microenvironment (TME) are the premises of tumor occurrence, development, and metastasis. The relationship among different components of the TME constitutes a three-dimensional network. We point out the core position of the Hippo pathway in this network and discuss how the regulatory inputs cause the chain reaction of the network. We also discuss the important role of Hippo-TME involvement in cancer treatment.
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spelling pubmed-86325472021-12-01 The Hippo Signaling Pathway: The Trader of Tumor Microenvironment Yang, Duo Zhang, Na Li, Meihua Hong, Tao Meng, Wei Ouyang, Taohui Front Oncol Oncology The Hippo pathway regulates cancer biology in many aspects and the crosstalk with other pathways complicates its role. Accumulated evidence has shown that the bidirectional interactions between tumor cells and tumor microenvironment (TME) are the premises of tumor occurrence, development, and metastasis. The relationship among different components of the TME constitutes a three-dimensional network. We point out the core position of the Hippo pathway in this network and discuss how the regulatory inputs cause the chain reaction of the network. We also discuss the important role of Hippo-TME involvement in cancer treatment. Frontiers Media S.A. 2021-11-11 /pmc/articles/PMC8632547/ /pubmed/34858852 http://dx.doi.org/10.3389/fonc.2021.772134 Text en Copyright © 2021 Yang, Zhang, Li, Hong, Meng and Ouyang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Yang, Duo
Zhang, Na
Li, Meihua
Hong, Tao
Meng, Wei
Ouyang, Taohui
The Hippo Signaling Pathway: The Trader of Tumor Microenvironment
title The Hippo Signaling Pathway: The Trader of Tumor Microenvironment
title_full The Hippo Signaling Pathway: The Trader of Tumor Microenvironment
title_fullStr The Hippo Signaling Pathway: The Trader of Tumor Microenvironment
title_full_unstemmed The Hippo Signaling Pathway: The Trader of Tumor Microenvironment
title_short The Hippo Signaling Pathway: The Trader of Tumor Microenvironment
title_sort hippo signaling pathway: the trader of tumor microenvironment
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8632547/
https://www.ncbi.nlm.nih.gov/pubmed/34858852
http://dx.doi.org/10.3389/fonc.2021.772134
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