Enhanced differentiation of functional human T cells in NSGW41 mice with tissue-specific expression of human interleukin-7

Humanized mouse models have become increasingly valuable tools to study human hematopoiesis and infectious diseases. However, human T-cell differentiation remains inefficient. We generated mice expressing human interleukin-7 (IL-7), a critical growth and survival factor for T cells, under the contro...

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Detalles Bibliográficos
Autores principales: Coppin, Emilie, Sundarasetty, Bala Sai, Rahmig, Susann, Blume, Jonas, Verheyden, Nikita A., Bahlmann, Franz, Ravens, Sarina, Schubert, Undine, Schmid, Janine, Ludwig, Stefan, Geissler, Katharina, Guntinas-Lichius, Orlando, von Kaisenberg, Constantin, Groten, Tanja, Platz, Alexander, Naumann, Ronald, Ludwig, Barbara, Prinz, Immo, Waskow, Claudia, Krueger, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8632686/
https://www.ncbi.nlm.nih.gov/pubmed/33976371
http://dx.doi.org/10.1038/s41375-021-01259-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8632686/
https://www.ncbi.nlm.nih.gov/pubmed/33976371
http://dx.doi.org/10.1038/s41375-021-01259-5

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