Metabolic alterations mediated by STAT3 promotes drug persistence in CML

Leukemic stem cells (LSCs) can acquire non-mutational resistance following drug treatment leading to therapeutic failure and relapse. However, oncogene-independent mechanisms of drug persistence in LSCs are incompletely understood, which is the primary focus of this study. We integrated proteomics,...

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Detalles Bibliográficos
Autores principales: Patel, Sweta B., Nemkov, Travis, Stefanoni, Davide, Benavides, Gloria A., Bassal, Mahmoud A., Crown, Brittany L., Matkins, Victoria R., Camacho, Virginia, Kuznetsova, Valeriya, Hoang, Ashley T., Tenen, Danielle E., Wolock, Samuel L., Park, Jihye, Ying, Li, Yue, Zongliang, Chen, Jake Y., Yang, Henry, Tenen, Daniel G., Ferrell, Paul Brent, Lu, Rui, Darley-Usmar, Victor, D’Alessandro, Angelo, Bhatia, Ravi, Welner, Robert S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8632690/
https://www.ncbi.nlm.nih.gov/pubmed/34120146
http://dx.doi.org/10.1038/s41375-021-01315-0

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