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Thoroughly Calibrated Modular Agent-Based Model of the Human Cardiovascular and Renal Systems for Blood Pressure Regulation in Health and Disease

Here we present a modular agent-based mathematical model of the human cardiovascular and renal systems. It integrates the previous models primarily developed by A. C. Guyton, F. Karaaslan, K. M. Hallow, and Y. V. Solodyannikov. We performed the model calibration to find an equilibrium state within t...

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Autores principales: Kutumova, Elena, Kiselev, Ilya, Sharipov, Ruslan, Lifshits, Galina, Kolpakov, Fedor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8632703/
https://www.ncbi.nlm.nih.gov/pubmed/34867451
http://dx.doi.org/10.3389/fphys.2021.746300
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author Kutumova, Elena
Kiselev, Ilya
Sharipov, Ruslan
Lifshits, Galina
Kolpakov, Fedor
author_facet Kutumova, Elena
Kiselev, Ilya
Sharipov, Ruslan
Lifshits, Galina
Kolpakov, Fedor
author_sort Kutumova, Elena
collection PubMed
description Here we present a modular agent-based mathematical model of the human cardiovascular and renal systems. It integrates the previous models primarily developed by A. C. Guyton, F. Karaaslan, K. M. Hallow, and Y. V. Solodyannikov. We performed the model calibration to find an equilibrium state within the normal vital sign ranges for a healthy adult. We verified the model’s abilities to reproduce equilibrium states with abnormal physiological values related to different combinations of cardiovascular diseases (such as systemic hypertension, chronic heart failure, pulmonary hypertension, etc.). For the model creation and validation, we involved over 200 scientific studies covering known models of the human cardiovascular and renal functions, biosimulation platforms, and clinical measurements of physiological quantities in normal and pathological conditions. We compiled detailed documentation describing all equations, parameters and variables of the model with justification of all formulas and values. The model is implemented in BioUML and available in the web-version of the software.
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spelling pubmed-86327032021-12-02 Thoroughly Calibrated Modular Agent-Based Model of the Human Cardiovascular and Renal Systems for Blood Pressure Regulation in Health and Disease Kutumova, Elena Kiselev, Ilya Sharipov, Ruslan Lifshits, Galina Kolpakov, Fedor Front Physiol Physiology Here we present a modular agent-based mathematical model of the human cardiovascular and renal systems. It integrates the previous models primarily developed by A. C. Guyton, F. Karaaslan, K. M. Hallow, and Y. V. Solodyannikov. We performed the model calibration to find an equilibrium state within the normal vital sign ranges for a healthy adult. We verified the model’s abilities to reproduce equilibrium states with abnormal physiological values related to different combinations of cardiovascular diseases (such as systemic hypertension, chronic heart failure, pulmonary hypertension, etc.). For the model creation and validation, we involved over 200 scientific studies covering known models of the human cardiovascular and renal functions, biosimulation platforms, and clinical measurements of physiological quantities in normal and pathological conditions. We compiled detailed documentation describing all equations, parameters and variables of the model with justification of all formulas and values. The model is implemented in BioUML and available in the web-version of the software. Frontiers Media S.A. 2021-11-11 /pmc/articles/PMC8632703/ /pubmed/34867451 http://dx.doi.org/10.3389/fphys.2021.746300 Text en Copyright © 2021 Kutumova, Kiselev, Sharipov, Lifshits and Kolpakov. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Kutumova, Elena
Kiselev, Ilya
Sharipov, Ruslan
Lifshits, Galina
Kolpakov, Fedor
Thoroughly Calibrated Modular Agent-Based Model of the Human Cardiovascular and Renal Systems for Blood Pressure Regulation in Health and Disease
title Thoroughly Calibrated Modular Agent-Based Model of the Human Cardiovascular and Renal Systems for Blood Pressure Regulation in Health and Disease
title_full Thoroughly Calibrated Modular Agent-Based Model of the Human Cardiovascular and Renal Systems for Blood Pressure Regulation in Health and Disease
title_fullStr Thoroughly Calibrated Modular Agent-Based Model of the Human Cardiovascular and Renal Systems for Blood Pressure Regulation in Health and Disease
title_full_unstemmed Thoroughly Calibrated Modular Agent-Based Model of the Human Cardiovascular and Renal Systems for Blood Pressure Regulation in Health and Disease
title_short Thoroughly Calibrated Modular Agent-Based Model of the Human Cardiovascular and Renal Systems for Blood Pressure Regulation in Health and Disease
title_sort thoroughly calibrated modular agent-based model of the human cardiovascular and renal systems for blood pressure regulation in health and disease
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8632703/
https://www.ncbi.nlm.nih.gov/pubmed/34867451
http://dx.doi.org/10.3389/fphys.2021.746300
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