Atomic-scale insights into allosteric inhibition and evolutional rescue mechanism of Streptococcus thermophilus Cas9 by the anti-CRISPR protein AcrIIA6

CRISPR-Cas systems are prokaryotic adaptive immunity against invading phages and plasmids. Phages have evolved diverse protein inhibitors of CRISPR-Cas systems, called anti-CRISPR (Acr) proteins, to neutralize this CRISPR machinery. In response, bacteria have co-evolved Cas variants to escape phage’...

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Detalles Bibliográficos
Autores principales: Li, Xinyi, Wang, Chengxiang, Peng, Ting, Chai, Zongtao, Ni, Duan, Liu, Yaqin, Zhang, Jian, Chen, Ting, Lu, Shaoyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8632846/
https://www.ncbi.nlm.nih.gov/pubmed/34900128
http://dx.doi.org/10.1016/j.csbj.2021.11.010

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