A DAP5/eIF3d alternate mRNA translation mechanism promotes differentiation and immune suppression by human regulatory T cells

Regulatory T cells (Treg cells) inhibit effector T cells and maintain immune system homeostasis. Treg cell maturation in peripheral sites requires inhibition of protein kinase mTORC1 and TGF-beta-1 (TGF-beta). While Treg cell maturation requires protein synthesis, mTORC1 inhibition downregulates it,...

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Detalles Bibliográficos
Autores principales: Volta, Viviana, Pérez-Baos, Sandra, de la Parra, Columba, Katsara, Olga, Ernlund, Amanda, Dornbaum, Sophie, Schneider, Robert J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8632918/
https://www.ncbi.nlm.nih.gov/pubmed/34848685
http://dx.doi.org/10.1038/s41467-021-27087-w

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