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Improved Dry Eye Symptoms and Signs of Patients With Meibomian Gland Dysfunction by a Dietary Supplement

Purpose: To explore the therapeutic effect of a dietary supplement on dry eye with meibomian gland dysfunction (MGD). Methods: Sixty patients with MGD-related dry eye were included in this prospective and randomized, placebo-controlled study. All the subjects were treated with eye hot compress, arti...

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Autores principales: Liu, Kangcheng, Chan, Yau Kei, Peng, Xia, Yuan, Ruolan, Liao, Min, Liang, Jingwen, Tang, Xiangbo, Xu, Yi, Cai, Yingjun, Li, Qiangxiang, Wang, Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8632949/
https://www.ncbi.nlm.nih.gov/pubmed/34869485
http://dx.doi.org/10.3389/fmed.2021.769132
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author Liu, Kangcheng
Chan, Yau Kei
Peng, Xia
Yuan, Ruolan
Liao, Min
Liang, Jingwen
Tang, Xiangbo
Xu, Yi
Cai, Yingjun
Li, Qiangxiang
Wang, Hua
author_facet Liu, Kangcheng
Chan, Yau Kei
Peng, Xia
Yuan, Ruolan
Liao, Min
Liang, Jingwen
Tang, Xiangbo
Xu, Yi
Cai, Yingjun
Li, Qiangxiang
Wang, Hua
author_sort Liu, Kangcheng
collection PubMed
description Purpose: To explore the therapeutic effect of a dietary supplement on dry eye with meibomian gland dysfunction (MGD). Methods: Sixty patients with MGD-related dry eye were included in this prospective and randomized, placebo-controlled study. All the subjects were treated with eye hot compress, artificial tears, and antibiotic ointment. After that, the patients received dietary supplementary or placebo daily for 12 weeks. The dry eye signs, function of MG, and visual quality of the patients were assessed at 4, 8, and 12 weeks after the treatment. Results: Twelve weeks after the treatment, patients who received dietary supplement had a significantly better improvement of dry eye symptoms, in terms of ocular surface diseases index and tear breaking-up time (TBUT), than those who received placebo (P < 0.05). The functions of MG, in terms of meibum quality and MG exclusion and MG obstruction scores, were significantly improved in both dietary supplement and placebo groups (P < 0.05). Patients who received dietary supplement had a significantly better improvement in the MG structure, in terms of acinar diameter and acinar density, than those who received placebo (P < 0.05). The number of inflammatory cells near MG was significantly lower in the dietary supplement group when compared with the placebo group (P < 0.05). The objective visual quality was significantly improved in the dietary supplement group, but not in the placebo group (P < 0.05). Conclusion: The dietary supplement can effectively improve the symptoms and signs of MGD-related dry eye, reduce the inflammatory reaction of MG, restore the gland structure, and indirectly improve the visual quality.
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spelling pubmed-86329492021-12-02 Improved Dry Eye Symptoms and Signs of Patients With Meibomian Gland Dysfunction by a Dietary Supplement Liu, Kangcheng Chan, Yau Kei Peng, Xia Yuan, Ruolan Liao, Min Liang, Jingwen Tang, Xiangbo Xu, Yi Cai, Yingjun Li, Qiangxiang Wang, Hua Front Med (Lausanne) Medicine Purpose: To explore the therapeutic effect of a dietary supplement on dry eye with meibomian gland dysfunction (MGD). Methods: Sixty patients with MGD-related dry eye were included in this prospective and randomized, placebo-controlled study. All the subjects were treated with eye hot compress, artificial tears, and antibiotic ointment. After that, the patients received dietary supplementary or placebo daily for 12 weeks. The dry eye signs, function of MG, and visual quality of the patients were assessed at 4, 8, and 12 weeks after the treatment. Results: Twelve weeks after the treatment, patients who received dietary supplement had a significantly better improvement of dry eye symptoms, in terms of ocular surface diseases index and tear breaking-up time (TBUT), than those who received placebo (P < 0.05). The functions of MG, in terms of meibum quality and MG exclusion and MG obstruction scores, were significantly improved in both dietary supplement and placebo groups (P < 0.05). Patients who received dietary supplement had a significantly better improvement in the MG structure, in terms of acinar diameter and acinar density, than those who received placebo (P < 0.05). The number of inflammatory cells near MG was significantly lower in the dietary supplement group when compared with the placebo group (P < 0.05). The objective visual quality was significantly improved in the dietary supplement group, but not in the placebo group (P < 0.05). Conclusion: The dietary supplement can effectively improve the symptoms and signs of MGD-related dry eye, reduce the inflammatory reaction of MG, restore the gland structure, and indirectly improve the visual quality. Frontiers Media S.A. 2021-11-12 /pmc/articles/PMC8632949/ /pubmed/34869485 http://dx.doi.org/10.3389/fmed.2021.769132 Text en Copyright © 2021 Liu, Chan, Peng, Yuan, Liao, Liang, Tang, Xu, Cai, Li and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Liu, Kangcheng
Chan, Yau Kei
Peng, Xia
Yuan, Ruolan
Liao, Min
Liang, Jingwen
Tang, Xiangbo
Xu, Yi
Cai, Yingjun
Li, Qiangxiang
Wang, Hua
Improved Dry Eye Symptoms and Signs of Patients With Meibomian Gland Dysfunction by a Dietary Supplement
title Improved Dry Eye Symptoms and Signs of Patients With Meibomian Gland Dysfunction by a Dietary Supplement
title_full Improved Dry Eye Symptoms and Signs of Patients With Meibomian Gland Dysfunction by a Dietary Supplement
title_fullStr Improved Dry Eye Symptoms and Signs of Patients With Meibomian Gland Dysfunction by a Dietary Supplement
title_full_unstemmed Improved Dry Eye Symptoms and Signs of Patients With Meibomian Gland Dysfunction by a Dietary Supplement
title_short Improved Dry Eye Symptoms and Signs of Patients With Meibomian Gland Dysfunction by a Dietary Supplement
title_sort improved dry eye symptoms and signs of patients with meibomian gland dysfunction by a dietary supplement
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8632949/
https://www.ncbi.nlm.nih.gov/pubmed/34869485
http://dx.doi.org/10.3389/fmed.2021.769132
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